| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 2 alpha kinase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:20:00 | The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression. | 32299090 |
| 2020-05-30 11:32:00 | mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway; the OMA1-DELE1-HRI pathway represents a potential therapeutic target that could enable fine-tuning of the integrated stress response for beneficial outcomes in diseases that involve mitochondrial dysfunction | 32132707 |
| 2020-05-16 11:46:00 | Human disorders associated with deleterious variants in EIF2AK1 and EIF2AK2 have not been reported. | 32197074 |
| 2020-03-07 10:24:00 | Recently, HRI has been implicated in the regulation of human fetal hemoglobin production. Therefore, HRI-integrated stress response has emerged as a potential therapeutic target for hemoglobinopathies. especially under iron/heme deficiency and beta-thalassemia. [review] | 31554636 |
| 2018-12-22 10:31:00 | Activation of HRI is mediated by Hsp90 during stress through modulation of the HRI-Hsp90 complex | 30170366 |
| Type | IDs |
|---|---|
| Synonymous | HCR, HRI |
| Gene |
UniProtKB-ID:
E2AK1_HUMAN,
A0A024QZU1_HUMAN
UniprotKB:
Q9BQI3,
A0A024QZU1
UniParc:
UPI000000166A,
UPI0000161BAE
EMBL:
AF181071,
CH236963,
AF255050,
AK290327,
AK075192,
CH878731,
AF116634,
AL136563,
AB037790,
AF100784,
AL834494,
AF183414,
BC006524,
AF147094
Ensembl:
ENSG00000086232
KO:
hsa:27102
|
| Nucleutide sequences |
EMBL-CDS:
BAC11461.1,
AAF71057.1,
AAF66736.1,
AAP97223.1,
EAW55049.1,
AAH06524.1,
BAA92607.1,
EAL23714.1,
AAG09683.1,
CAD39152.1,
BAF83016.1,
AAF70289.1,
CAB66498.1,
AAF18391.1,
EAW55051.1
Gene_ORFName:
PRO1362,
hCG_2008663
Ensembl_TRS:
ENST00000199389
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000199389
RefSeq:
XP_024302486.1,
NP_001127807.1,
NP_055228.2
|
| Others |
UniRef100:
UniRef100_Q9BQI3
UniRef90:
UniRef90_Q9BQI3
UniRef50:
UniRef50_Q9Z2R9
UniGene:
Hs.520205
CCDS:
CCDS5345.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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