| Type | Description |
|---|---|
| Definition | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like |
| Date | Results | Publications |
|---|---|---|
| 2019-01-12 10:58:00 | This study performed untargeted metabolomics on whole Mthfd1l-null and wildtype mouse embryos in combination with isotope tracer analysis in mouse embryonic fibroblast cell lines to identify Mthfd1l deletion-induced disruptions in 1-carbon metabolism, glycolysis, and the TCA cycle. Mthfd1l-null fibroblasts have altered methionine synthesis, indicating that Mthfd1l deletion impairs the methyl cycle. | 29483189 |
| 2013-03-09 10:24:00 | Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice. | 23267094 |
| 2010-05-31 12:03:00 | Data show that the MTHFD1L enzyme is present in mitochondria from normal embryonic tissues and embryonic fibroblast cell lines, and embryonic mitochondria possess the ability to synthesize formate from glycine. | 19948730 |
| Type | IDs |
|---|---|
| Synonymous | 2410004L15Rik, AI647056, Fthfsdc1 |
| Gene |
UniProtKB-ID:
C1TM_MOUSE
UniprotKB:
Q3V3R1
UniParc:
UPI0000D63309
EMBL:
AK160025,
BC049936,
AK036284,
AK028211,
AK038579,
BC030437
Ensembl:
ENSMUSG00000040675
KO:
mmu:270685
|
| Nucleutide sequences |
EMBL-CDS:
BAE20438.1,
BAE35568.1,
BAC30053.1,
BAE20500.1,
AAH30437.1,
AAH49936.1
Ensembl_TRS:
ENSMUST00000120585,
ENSMUST00000043735,
ENSMUST00000117291
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000036178,
ENSMUSP00000112897,
ENSMUSP00000112870
RefSeq:
XP_036011689.1,
NP_001164257.1,
NP_758512.3,
NP_001164256.1,
XP_036011688.1
|
| Others |
UniRef100:
UniRef100_Q3V3R1
UniRef90:
UniRef90_Q3V3R1
UniRef50:
UniRef50_Q3V3R1
UniGene:
Mm.184752
CCDS:
CCDS56672.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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