| Type | Description |
|---|---|
| Definition | T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 13:03:00 | Knockdown of Tcirg1 inhibits large-osteoclast generation by down-regulating NFATc1 and IP3R2 expression. | 32790690 |
| 2019-10-05 11:48:00 | a3 directly interacted with the GDP-bound forms of Rab7 and Rab27A. These findings reveal a novel role for the proton pump V-ATPase in secretory lysosome trafficking and an unexpected mechanistic link with Rab GTPases. | 29712939 |
| 2014-05-10 14:13:00 | Here we show mice homozygous for R740S (R740S/R740S) of the Vacuolar-type H(+)-ATPases have more severe osteopetrosis and die by postnatal day 14 | 23908015 |
| 2013-09-28 11:28:00 | Luteolin can be effective in reducing bone resorption and that this effect of luteolin may be through disruption of osteoclast V-ATPase a3-d2 interaction. | 23129004 |
| 2013-05-25 10:59:00 | increased lysosomal pH in V ATPase a3 mutant mice osteoclasts leads to decreased NFATc1 signaling and nuclear translocation, resulting in a cell autonomous impairment of osteoclastogenesis in vitro. | 22865292 |
| Type | IDs |
|---|---|
| Synonymous | ATP6N1C, ATP6a3, Atp6i, OC-116, OPTB1, Stv1, TIRC7, Vph1, oc |
| Gene |
UniProtKB-ID:
Q9JHF5_MOUSE
UniprotKB:
Q9JHF5
UniParc:
UPI0000020BB4
EMBL:
AF188702,
AC133523,
AB022322
Ensembl:
ENSMUSG00000001750
KO:
mmu:27060
|
| Nucleutide sequences |
EMBL-CDS:
AAF37193.1,
BAA93006.1
Ensembl_TRS:
ENSMUST00000145791,
ENSMUST00000001801,
ENSMUST00000126070
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000122474,
ENSMUSP00000001801,
ENSMUSP00000120531
RefSeq:
NP_001129563.1,
NP_058617.3,
XP_011246934.1,
NP_001161256.1
|
| Others |
UniRef100:
UniRef100_Q9JHF5
UniRef90:
UniRef90_Q9JHF5
UniRef50:
UniRef50_Q13488
UniGene:
Mm.271689
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员