| Type | Description |
|---|---|
| Definition | contains a RING finger; disrupts ND10; proteasome-dependent degradation of several cellular proteins; involved in gene regulation; involved in cellular protein degradation; involved in latency |
| Date | Results | Publications |
|---|---|---|
| 2019-05-07 16:49:00 | data show that infected cell protein 0 (ICP0) binds CIN85 in a reciprocal manner and that the complexes pulled down by ICP0 also contain Cbl | 15824310 |
| 2018-06-30 12:05:00 | Data suggest that intracellular host defenses are counteracted by ICP0, which targets PML for degradation from the outset of nuclear infection to promote viral-DNA release from PML-nuclear bodies and the onset of HSV-1 lytic replication. (ICP0 = immediate early infected polypeptide-0; PML = promyelocytic leukemia protein; HSV-1 = herpes simplex virus-1) | 29309427 |
| 2017-08-26 10:43:00 | The Nbs1 homologs that promote herpes simplex virus 1 infection also interact with the herpes simplex virus 1 ICP0 protein. | 27512903 |
| 2017-07-29 12:39:00 | no evidence was found that miR-H2 represses the expression of ICP0 in cells or mice infected with HSV-1. | 27847363 |
| 2017-05-20 11:44:00 | An HSV-1 protein, ICP0, can recognize individual host factors and target them differently for destruction. We identified elements that are important for the ICP0 E3 ubiquitin ligase to differentially recognize two of its substrates, isoforms PML I and PML II. | 27681131 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
ICP0_HHV11,
G8HBH2_HHV1
UniprotKB:
P08393,
G8HBH2
UniParc:
UPI000012D178
EMBL:
MN159377,
MN159376,
X04614,
MN159382,
X14112,
JN555585
KO:
vg:2703389,
vg:2703390
|
| Nucleutide sequences |
EMBL-CDS:
CAA32293.1,
CAA32336.1,
CAA28285.1,
AEQ77030.1,
QEU44979.1,
QEU45418.1,
AEQ77089.1,
QEU44904.1,
QEU44963.1,
QEU45037.1
|
| Protein sequencees |
RefSeq:
YP_009137133.1
|
| Others |
UniRef100:
UniRef100_P08393
UniRef90:
UniRef90_P08393
UniRef50:
UniRef50_P08393
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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