| Type | Description |
|---|---|
| Definition | polymerase (DNA directed), kappa |
| Date | Results | Publications |
|---|---|---|
| 2019-04-27 12:03:00 | The results indicate that Polkappa does not suppress benzo[a]pyrene -induced mutagenesis and carcinogenesis in the colon, but counteracts inflammation-induced mutagenesis in multiple organs. | 30620413 |
| 2017-12-02 11:16:00 | The results suggest that Polk has a limited ability to suppress BP-induced genotoxicity in the colon and bone marrow and also that the roles of specialized DNA polymerases in mutagenesis and carcinogenesis should be examined not only by in vitro assays but also by in vivo mouse studies. We also report the spontaneous mutagenesis in inactivated Polk KI mice at young and old ages. | 29076178 |
| 2016-10-29 12:03:00 | the extreme N-terminal part of Polkappa is required for the processivity and fidelity of Polkappa during translesion synthesis of 10S(+)-trans-anti-benzo[a]pyrene diol epoxide-N(2)-deoxyguanine adducts lesions. | 26634445 |
| 2015-10-24 10:46:00 | Polk plays a predominant role in suppressing point mutations by carrying out error-free translesion DNA synthesis and contributes to the prevention of DNA strand breaks. | 25303778 |
| 2014-04-05 10:57:00 | The structural gap physically accommodates the bulky aromatic adduct and the N-clasp is essential for the structural integrity and flexibility of Polkappa during translesion synthesis. | 24449898 |
| Type | IDs |
|---|---|
| Synonymous | DINP, Dinb1 |
| Gene |
UniProtKB-ID:
POLK_MOUSE,
Q5Q9H7_MOUSE,
Q5Q9H6_MOUSE,
A0A1Y7VIV8_MOUSE,
Q3UUL1_MOUSE,
Q5Q9H0_MOUSE,
Q9CRV6_MOUSE
UniprotKB:
Q9QUG2,
Q5Q9H7,
Q5Q9H6,
A0A1Y7VIV8,
Q3UUL1,
Q5Q9H0,
Q9CRV6
UniParc:
UPI0000497869,
UPI0000021C98,
UPI0000497863,
UPI0000565558,
UPI0000497862,
UPI00004C8014,
UPI00005ABE13,
UPI00000E8A0F
EMBL:
AY769920,
AK014087,
AK138299,
AC122828,
AC125534,
AF163571,
AY769921,
AB027563,
AB040765,
BC052820,
AY769927
Ensembl:
ENSMUSG00000021668
KO:
mmu:27015
|
| Nucleutide sequences |
EMBL-CDS:
BAA86942.1,
BAB59059.1,
AAF02541.1,
AAH52820.1,
AAV80818.1,
AAV80819.1,
BAE23614.1,
AAV80825.1,
BAB29148.1
Ensembl_TRS:
ENSMUST00000022172,
ENSMUST00000091387,
ENSMUST00000221899,
ENSMUST00000221645,
ENSMUST00000222389
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000022172,
ENSMUSP00000088950,
ENSMUSP00000152647,
ENSMUSP00000152178,
ENSMUSP00000152192
RefSeq:
NP_036178.1,
XP_036013954.1,
NP_001334532.1,
XP_006517743.1,
XP_036013953.1,
NP_001334533.1,
NP_001334531.1,
XP_030103145.1,
NP_001334535.1
|
| Others |
UniRef100:
UniRef100_Q9QUG2,
UniRef100_Q5Q9H0,
UniRef100_A0A1Y7VIV8,
UniRef100_Q5Q9H7,
UniRef100_Q5Q9H6
UniRef90:
UniRef90_A0A1Y7VIV8,
UniRef90_Q9QUG2
UniRef50:
UniRef50_Q9UBT6,
UniRef50_Q9UBT6-3
UniGene:
Mm.89926
CCDS:
CCDS26704.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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