| Type | Description |
|---|---|
| Definition | glutaryl-Coenzyme A dehydrogenase |
| Date | Results | Publications |
|---|---|---|
| 2019-04-06 10:50:00 | myelin damage seen in Gcdh-/- mice fed with 2.8% Lys seems to be mediated by a long-term increased levels of Glutaric acidemia type I metabolites having deleterious effects in myelinating oligodendrocytes over neurons. | 29779173 |
| 2018-12-22 10:44:00 | The present data indicate that QA significantly contributes to the histopathological changes observed in the striatum of Gcdh-/- mice. | 29235064 |
| 2018-12-01 12:26:00 | Elevated glutaric acid levels in Dhtkd1-/Gcdh- double knockout mice challenge our current understanding of lysine metabolism. | 28545977 |
| 2018-01-27 10:45:00 | Quinolinic acid increased lactate release in both Gcdh (+/+) and Gcdh (-/-) mice and reduced the activities of complex IV and creatine kinase only in the striatum of Gcdh (-/-) mice. | 26607633 |
| 2017-10-14 11:27:00 | Using an experimental model with a phenotype similar to that of GA-I in humans-the Gcdh(-/-) mice under high lysine diet (Gcdh(-/-) -Lys)-we provide evidence that a reduction in cortical inhibition of Gcdh(-/-) -Lys mice, probably induced by GAD dysfunction, leads to hyperexcitability and increased slow oscillations associated with neurologic abnormalities in glutaric academia type I. | 28762469 |
| Type | IDs |
|---|---|
| Synonymous | 9030411L18, AI266902, D17825, GCD |
| Gene |
UniProtKB-ID:
GCDH_MOUSE,
A0A0A0MQ68_MOUSE,
Q8BVD4_MOUSE
UniprotKB:
Q60759,
A0A0A0MQ68,
Q8BVD4
UniParc:
UPI00000EA91A,
UPI0002651317,
UPI0000020D91
EMBL:
KY499700,
U18992,
AC161765,
AK165406,
AK078866,
BC061158
Ensembl:
ENSMUSG00000003809
KO:
mmu:270076
|
| Nucleutide sequences |
EMBL-CDS:
AAH61158.1,
BAE38166.1,
AAB04679.1,
AQS27621.1,
BAC37429.1
Ensembl_TRS:
ENSMUST00000109745,
ENSMUST00000003907
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000105367,
ENSMUSP00000003907
RefSeq:
NP_032123.3,
NP_001038209.2,
XP_036009971.1
|
| Others |
UniRef100:
UniRef100_Q60759
UniRef90:
UniRef90_Q60759
UniRef50:
UniRef50_Q92947
UniGene:
Mm.2475
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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