| Type | Description |
|---|---|
| Definition | calcium dependent secretion activator |
| Date | Results | Publications |
|---|---|---|
| 2017-05-20 14:34:00 | The unique tandem C2-PH domain of CAPS may serve as a PI(4,5)P2-triggered switch for dimerization. CAPS dimerization may be coupled to oligomeric SNARE complex assembly for vesicle docking and priming. | 27528604 |
| 2016-09-24 10:19:00 | results indicate that dense-core vesicles carry CAPS to sites of exocytosis, where CAPS promotes vesicle docking and fusion competence, probably by initiating SNARE complex assembly. | 26700319 |
| 2015-01-17 10:43:00 | Transport vesicle fusion into PIP2-rich membrane domains is facilitated by sequential PIP2-dependent activation of CAPS and PIP2-dependent recruitment of Munc13. | 24356451 |
| 2013-11-02 11:04:00 | CAPS1 binds to the full-length of cytoplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1. | 23801330 |
| 2012-01-07 10:47:00 | The results show that Munc13 homology domain-1 is a SNARE-binding domain and that SNARE protein binding is essential for CAPS function in dense-core vesicle exocytosis. | 21803295 |
| Type | IDs |
|---|---|
| Synonymous | Caps, Caps1, Caps2 |
| Gene |
UniProtKB-ID:
CAPS1_RAT
UniprotKB:
Q62717
UniParc:
UPI00000E6598
EMBL:
U16802
KO:
rno:26989
|
| Nucleutide sequences |
EMBL-CDS:
AAB88635.1
|
| Protein sequencees |
RefSeq:
NP_037351.1
|
| Others |
UniRef100:
UniRef100_Q62717
UniRef90:
UniRef90_Q62717
UniRef50:
UniRef50_Q62717
UniGene:
Rn.88197
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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