| Type | Description |
|---|---|
| Definition | ORAI calcium release-activated calcium modulator 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:43:00 | ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense. | 32929002 |
| 2020-04-04 12:15:00 | Calcium signals induced by calcium store depletion or oxygen/glucose deprivation were significantly diminished in Orai2-deficient neurons demonstrating that Orai2 is a central mediator of neuronal capacitative Ca(2+) entry and is involved in calcium overload during ischemia. | 31551038 |
| 2018-12-22 11:18:00 | Orai2 proteins contribute to Ca(2+) entry in connective tissue type mast cells in discrete operation modes depending on the availability of calcium ions in the extracellular space. | 29604961 |
| 2018-11-10 10:42:00 | ORAI1 and ORAI2 form heteromeric Ca(2+) release-activated Ca(2+) channels, in which ORAI2 fine-tunes the magnitude of Store-operated Ca(2+) entry to modulate immune responses. | 28294127 |
| 2017-08-19 11:47:00 | This study demonstrated that Transient Receptor Potential Canonical 6 (TRPC6) and Orai2 form stromal interaction molecule 2 (STIM2)-regulated neuronal-store-operated Ca(2+) influx (nSOC) channel complex in hippocampal synapse and the resulting Ca(2+) influx is critical for long-term maintenance of mushroom spines in hippocampal neurons. | 27881772 |
| Type | IDs |
|---|---|
| Synonymous | A730041O15Rik, Tmem142b |
| Gene |
UniProtKB-ID:
ORAI2_MOUSE,
A5CVE1_MOUSE,
Q14BR6_MOUSE
UniprotKB:
Q8BH10,
A5CVE1,
Q14BR6
UniParc:
UPI000002507E,
UPI0000604FFF
EMBL:
BC115648,
BC066070,
AM712357,
AK036013,
BC115649,
AM712356,
AK042940,
AK079619,
AC087420
Ensembl:
ENSMUSG00000039747
KO:
mmu:269717
|
| Nucleutide sequences |
EMBL-CDS:
BAC31410.1,
AAH66070.1,
BAC37704.1,
BAC29276.1,
CAN36427.1,
AAI15649.1,
CAN36428.1,
AAI15650.1
Ensembl_TRS:
ENSMUST00000041048,
ENSMUST00000196454
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000037137,
ENSMUSP00000142597
RefSeq:
XP_006504492.1,
NP_848866.2,
XP_006504493.1,
XP_006504494.1
|
| Others |
UniRef100:
UniRef100_A5CVE1,
UniRef100_Q8BH10
UniRef90:
UniRef90_Q8BH10,
UniRef90_Q96SN7
UniRef50:
UniRef50_Q96SN7,
UniRef50_Q8BH10
UniGene:
Mm.308396
CCDS:
CCDS39326.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员