| Type | Description |
|---|---|
| Definition | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 |
| Date | Results | Publications |
|---|---|---|
| 2018-02-03 11:16:00 | Data show that pleckstrin homology containing family member 5 (Plekhg5)-depleted cultured motoneurons show defective axon growth and impaired autophagy of synaptic vesicles, which can be rescued by constitutively active ras-related protein Rab-26 (Rab26). | 29084947 |
| 2017-10-14 13:05:00 | Plekhg5 affects cell polarity, migration, adhesion, degradation, and podosome organization in macrophages and osteoclasts. | 28847484 |
| 2014-04-26 11:31:00 | Results indicate that different mutations in PLEKHG5 lead to clinically diverse outcomes Charcot-Marie-Tooth disease or lower motor neuron disease affecting the function of neurons and glial cells. | 23777631 |
| 2013-05-11 12:16:00 | a novel means of regulating junctional Syx localization and function by phosphorylation-induced 14-3-3 binding and further support the importance of Syx function in maintaining stable cell-cell contacts. | 23335514 |
| 2013-02-23 11:24:00 | VEGF causes translocation of Syx from cell junctions, promoting junction disassembly, whereas angiopoietin 1 maintains Syx at the junctions, inducing junction stabilization. | 23253477 |
| Type | IDs |
|---|---|
| Synonymous | BC023181, Syx |
| Gene |
UniProtKB-ID:
PKHG5_MOUSE,
A0A0A0MQC2_MOUSE,
B1AS67_MOUSE,
A0A2X0SG37_MOUSE,
A0A5F8MPI8_MOUSE
UniprotKB:
Q66T02,
A0A0A0MQC2,
B1AS67,
A0A2X0SG37,
A0A5F8MPI8
UniParc:
UPI0000428AD0,
UPI000042826B,
UPI0003D76EEE,
UPI000035697C,
UPI00001F1D88
EMBL:
BC023181,
AY605058,
AL772240,
LS482408,
BC064091,
AK129198,
AL611927,
AY605057
Ensembl:
ENSMUSG00000039713
KO:
mmu:269608
|
| Nucleutide sequences |
EMBL-CDS:
CAM24582.2,
AAH23181.1,
AAH64091.1,
CAM24581.1,
BAC98008.1,
CAM19699.2,
CAM19697.1,
AAU04953.1,
AAU04954.1,
SPT35785.1
Ensembl_TRS:
ENSMUST00000084115,
ENSMUST00000105661,
ENSMUST00000105662,
ENSMUST00000118648,
ENSMUST00000239025
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000081132,
ENSMUSP00000101286,
ENSMUSP00000101287,
ENSMUSP00000112707,
ENSMUSP00000158992
RefSeq:
XP_036020058.1,
XP_036020057.1,
XP_011248568.1,
XP_006538986.1,
XP_006538988.1,
NP_001272928.1,
XP_006538990.1,
XP_036020056.1,
XP_006538991.1,
NP_001361712.1
|
| Others |
UniRef100:
UniRef100_A0A5F8MPI8,
UniRef100_Q66T02,
UniRef100_B1AS67
UniRef90:
UniRef90_Q66T02
UniRef50:
UniRef50_Q66T02
UniGene:
Mm.332102,
Mm.486442
CCDS:
CCDS18987.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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