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2696 GIPR

2696

GIPR

gastric inhibitory polypeptide receptor

protein-coding

Homo sapiens

基因描述

Type Description
Definition gastric inhibitory polypeptide receptor

研究结论

Date Results Publications
2021-02-20 13:28:00 The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes. 31933128
2021-02-13 13:22:00 Predictive effect of GIPR SNP rs10423928 on glucose metabolism liver fat and adiposity in prediabetic and diabetic subjects. 31874232
2020-04-04 12:47:00 GIPR variants may play a role in disturbed glucose homeostasis and may be of clinical relevance in homozygous patients. 30784161
2020-02-29 10:08:00 Study describes a distinct molecular subclass of somatotropinomas, clinically revealed by a paradoxical increase of GH to oral glucose related to pituitary GIPR expression. This ectopic GIPR expression occurred through hypomorphic transcriptional activation and is likely driven by GIPR gene microamplifications and DNA methylation abnormalities. 30376114
2019-08-31 12:41:00 results provide insight into the molecular pathogenesis of GIP-dependent Cushing's syndrome, occurring through monoallelic transcriptional activation of GIPR driven in some adrenal lesions by structural variations 28931750

名称对应

Type IDs
Synonymous PGQTL2
Gene
UniProtKB-ID: GIPR_HUMAN
UniprotKB: P48546
UniParc: UPI000189A7C9, UPI0000EE6DB4, UPI00000503FD
EMBL: BC143300, AC006132, D49559, X81832, U39231, S79852, BC101673, AC007191, BC093723
Ensembl: ENSG00000010310
KO: hsa:2696
Nucleutide sequences
EMBL-CDS: AAB35419.2, BAA08503.1, AAA84418.1, AAI01674.1, AAD22674.1, AAC97984.1, CAA57426.1, AAI43301.1, AAH93723.1
Ensembl_TRS: ENST00000263281, ENST00000304207, ENST00000590918
Protein sequencees
Ensembl_PRO: ENSP00000263281, ENSP00000467494, ENSP00000305321
RefSeq: XP_011525016.1, XP_011525012.1, NP_001295347.1, XP_016882074.1, XP_011525018.1, XP_011525011.1, XP_016882073.1, XP_011525017.1, XP_011525015.1, NP_000155.1, XP_016882075.1, XP_016882076.1, XP_011525013.1
Others
UniRef100: UniRef100_P48546
UniRef90: UniRef90_P48546
UniRef50: UniRef50_P48546
UniGene: Hs.658534
CCDS: CCDS82367.1, CCDS12671.1

全选

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