| Type | Description |
|---|---|
| Definition | afadin, adherens junction formation factor |
| Date | Results | Publications |
|---|---|---|
| 2019-03-02 12:21:00 | Study found that afadin undergoes a bi-directional trafficking to both synaptic and nuclear compartment in response to acute 17beta-estradiol (estradiol) treatment, in mixed sex neuronal cultures derived from fetal cortex. Nuclear accumulation of afadin was coincidental with an increase in the phosphorylation of histone H3 at serine 10 (H3S10p). This epigenetic modification is associated with the remodeling of chromatin. | 30268521 |
| 2019-02-09 12:40:00 | Spatiotemporal and dynamic alternative splicing produces differential expression patterns of afadin isoforms and alternative splicing of afadin is controlled by the neuron-specific regulator(s) whose activity is triggered and dynamically altered during neuronal differentiation and maturation. | 30572094 |
| 2016-02-13 11:38:00 | Short splicing isoform of afadin (s-Afadin) blocks the R-Ras-mediated membrane translocation of long splicing isoform of afadin (l-afadin) and axon branching by inhibiting the binding of l-afadin to R-Ras. | 25808489 |
| 2014-06-21 11:11:00 | afadin bi-directional shuttling from the cytosol to synapses and the nucleus promotes spine plasticity and histone modifications | 24567331 |
| 2012-12-29 10:44:00 | afadin is required for the maintenance of dendritic structure and excitatory tone. | 22948147 |
| Type | IDs |
|---|---|
| Synonymous | Af6, Mllt4 |
| Gene |
UniProtKB-ID:
AFAD_RAT
UniprotKB:
O35889
UniParc:
UPI00000E815D,
UPI00000E668F
EMBL:
U83231,
U83230
KO:
rno:26955
|
| Nucleutide sequences |
EMBL-CDS:
AAC53391.1,
AAC53390.1
|
| Protein sequencees |
RefSeq:
NP_037349.1
|
| Others |
UniRef100:
UniRef100_O35889
UniRef90:
UniRef90_O35889
UniRef50:
UniRef50_O35889
UniGene:
Rn.58
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员