| Type | Description |
|---|---|
| Definition | ECSIT signalling integrator |
| Date | Results | Publications |
|---|---|---|
| 2019-06-22 11:02:00 | these results demonstrate a key role of ECSIT in complex I function, mitochondrial reactive oxygen species production, and mitophagy-dependent mitochondrial quality control. | 29514094 |
| 2019-05-11 12:55:00 | ECSIT-T419C knock-in mice showed higher peritoneal NADPH oxidase activity than mice with wild-type ECSIT in response to LPS. ECSIT-T419C-transfected ENKTL cell lines produced tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, which induced macrophage activation and massive cytokine secretion in cell culture and mouse xenografts. | 29291352 |
| 2010-01-21 00:00:00 | functions as an essential component in two important signal transduction pathways and establishes a novel role for Ecsit as a cofactor for Smad proteins in the bone morphogenetic protein signaling pathway | 14633973 |
| Type | IDs |
|---|---|
| Synonymous | Sitpec |
| Gene |
UniProtKB-ID:
ECSIT_MOUSE,
A0A0R4J174_MOUSE
UniprotKB:
Q9QZH6,
A0A0R4J174
UniParc:
UPI0000029FE0,
UPI00000E835D
EMBL:
AF182510,
BC004583,
AC163623,
BC016424
Ensembl:
ENSMUSG00000066839
KO:
mmu:26940
|
| Nucleutide sequences |
EMBL-CDS:
AAF01219.1,
AAH04583.1,
AAH16424.1
Ensembl_TRS:
ENSMUST00000180180,
ENSMUST00000179422,
ENSMUST00000098937
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000136247,
ENSMUSP00000137424,
ENSMUSP00000096537
RefSeq:
NP_001240827.1,
XP_030100256.1,
XP_011240841.1,
NP_001240826.1,
XP_011240840.1,
XP_006510433.1,
XP_011240842.1,
XP_030100255.1,
XP_036010916.1,
NP_036159.1
|
| Others |
UniRef100:
UniRef100_A0A0R4J174,
UniRef100_Q9QZH6
UniRef90:
UniRef90_Q9QZH6
UniRef50:
UniRef50_Q9BQ95
UniGene:
Mm.425568
CCDS:
CCDS22920.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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