| Type | Description |
|---|---|
| Definition | S-adenosylhomocysteine hydrolase |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 11:03:00 | Inhibition of DJ-1 potently enhances the sensitivity of tumor cells to ferroptosis inducers both in vitro and in vivo. Metabolic analysis and metabolite rescue assay reveal that DJ-1 depletion inhibits the transsulfuration pathway by disrupting the formation of the S-adenosyl homocysteine hydrolase tetramer and impairing its activity. Study findings show that DJ-1 determines the response of cancer cells to ferroptosis. | 32144268 |
| 2018-11-10 12:20:00 | These results indicate that epigenetically mediated inhibition of Ahcy expression may be a driving force in causing SAH elevation and subsequent downstream disturbances in transsulfuration and transmethylation pathways during the development and progression of nonalcoholic steatohepatitis. | 29127188 |
| 2016-05-14 11:49:00 | H19 knockdown activates SAHH, leading to increased DNMT3B-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19-Nctc1 locus. | 26687445 |
| 2011-06-18 10:51:00 | Ahcy was identified from coupling of methylation with gene expression data, shed light on the underlying mechanisms of cytosine demethylation under methyl-deficient conditions. | 20938992 |
| 2010-04-12 12:17:00 | report the crystallization of mouse SAHH in the presence of the reaction product adenosine. The crystals diffracted to at least 1.55 A degrees resolution and are suitable for X-ray structure analysis at high resolution. | 20208169 |
| Type | IDs |
|---|---|
| Synonymous | AA987153, AL024110, CuBP, SAHH |
| Gene |
UniProtKB-ID:
SAHH_MOUSE,
Q3TF14_MOUSE,
Q5M9P0_MOUSE
UniprotKB:
P50247,
Q3TF14,
Q5M9P0
UniParc:
UPI0000023BF9,
UPI0000498249
EMBL:
BC086781,
AK169331,
BC015304,
L32836,
BC108367
Ensembl:
ENSMUSG00000027597,
ENSMUSG00000048087
KO:
mmu:11615,
mmu:269378
|
| Nucleutide sequences |
EMBL-CDS:
AAA70378.1,
AAH15304.1,
BAE41084.1,
AAI08368.1,
AAH86781.1
Ensembl_TRS:
ENSMUST00000059524,
ENSMUST00000054607
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000127198,
ENSMUSP00000061851
RefSeq:
NP_057870.3
|
| Others |
UniRef100:
UniRef100_P50247,
UniRef100_Q5M9P0
UniRef90:
UniRef90_P23526
UniRef50:
UniRef50_P23526
UniGene:
Mm.330692,
Mm.371964
CCDS:
CCDS16942.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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