| Type | Description |
|---|---|
| Definition | senataxin |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:50:00 | Oocytes mount a noncanonical DNA damage response involving APC-Cdh1-mediated proteolysis. | 32328643 |
| 2019-09-21 11:14:00 | SETX ALS4 mice thus recapitulated ALS disease phenotypes in association with TDP-43 mislocalization and provided insight into the basis for TDP-43 histopathology, linking SETX dysfunction to common pathways of ALS motor neuron degeneration. | 29725819 |
| 2019-07-13 12:19:00 | Senataxin (SETX)-deficiency results in increased RNA-DNA hybrids (R-loops) and DNA double-strand breaks (DSBs), and deficiency of DNA-activated protein kinase-catalytic subunit (DNA-PKcs), which impairs DSB repair. SETX overexpression in SMA neurons reduces R-loops and DNA damage, and rescues neurodegeneration. | 30010942 |
| 2019-01-19 10:46:00 | Study report a previously uncharacterized protein, SAN1, the Fam120b gene product, as a 5' exonuclease that acts independently of the Fanconi anemia pathway in response to inter-strand DNA cross-links (ICLs). Deletion of SAN1 in HeLa cells and mouse embryonic fibroblasts causes sensitivity to ICLs. SAN1 binds to senataxin (SETX). SAN1-SETX binding is increased by ICLs and is required to prevent cross-link sensitivity. | 29968717 |
| 2015-04-25 11:31:00 | Results identify novel genes related to senataxin function in normal and disease states. | 24760770 |
| Type | IDs |
|---|---|
| Synonymous | A130090N03, A930037J23Rik, AOA2, AW060766, Als4, SCAR1, Sen1, mKIAA0625 |
| Gene |
UniProtKB-ID:
SETX_MOUSE
UniprotKB:
A2AKX3
UniParc:
UPI00015D778B,
UPI00005668D3
EMBL:
AL772379,
BC058109,
AK048354,
AK077911,
BK001523,
BC046382,
AK044730,
AK129177,
BC079604,
AL845267
Ensembl:
ENSMUSG00000043535
KO:
mmu:269254
|
| Nucleutide sequences |
EMBL-CDS:
AAH58109.2,
DAA01946.1,
BAC97987.1,
AAH46382.1,
BAC33309.2,
BAC32054.1,
AAH79604.2,
BAC37058.1
Ensembl_TRS:
ENSMUST00000061578
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000051492
RefSeq:
XP_006498142.1,
NP_932150.2,
XP_006498145.1,
XP_006498143.1,
XP_030107510.1
|
| Others |
UniRef100:
UniRef100_A2AKX3
UniRef90:
UniRef90_A2AKX3
UniRef50:
UniRef50_A2AKX3
UniGene:
Mm.41867
CCDS:
CCDS38090.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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