| Type | Description |
|---|---|
| Definition | endoplasmic reticulum (ER) to nucleus signalling 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:24:00 | Reactive oxygen species-mediated endoplasmic reticulum stress response induces apoptosis of Mycobacterium avium-infected macrophages by activating regulated IRE1-dependent decay pathway. | 31386788 |
| 2020-05-16 10:57:00 | Results suggest that inhibition of the IRE1 RNase activity and XBP1 markedly represses differentiation. In particular, IRE1 RNase activity is essential from the myoblast to early differentiation stage. | 31888027 |
| 2020-04-18 10:04:00 | Degradation of Blos1 mRNA by IRE1 promotes late endosome-mediated microautophagy of protein aggregates and protects cells from their cytotoxic effects. | 30787040 |
| 2020-02-29 11:59:00 | A positive feedback bistable ERN2-XBP1S pathway regulates MUC5B-dominated mucus obstruction in idiopathic pulmonary fibrosis (IPF), providing an unfolded protein response-dependent mechanism linking the MUC5B promoter rs35705950 polymorphism with IPF pathogenesis. | 30973754 |
| 2020-02-22 12:26:00 | S1R restricts the endonuclease activity of the endoplasmic reticulum stress sensor IRE1 and cytokine expression but does not inhibit the classical inflammatory signaling pathways. | 30728287 |
| Type | IDs |
|---|---|
| Synonymous | Ern1, Ire1, Ire1b, ire1-beta, mIre1 |
| Gene |
UniProtKB-ID:
ERN2_MOUSE,
Q3UTN5_MOUSE,
Q32MS5_MOUSE
UniprotKB:
Q9Z2E3,
Q3UTN5,
Q32MS5
UniParc:
UPI000024DF6B,
UPI00005DC6EE,
UPI00005ABECF
EMBL:
AF071777,
CH466531,
BC109000,
AK153659,
BC108999,
AC122232,
AK139291
Ensembl:
ENSMUSG00000030866
KO:
mmu:26918
|
| Nucleutide sequences |
EMBL-CDS:
EDL17275.1,
BAE32136.1,
AAC64400.1,
BAE23945.1,
AAI09001.1,
AAI09000.1
Ensembl_TRS:
ENSMUST00000033153,
ENSMUST00000206198
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033153,
ENSMUSP00000145716
RefSeq:
XP_011240122.1,
NP_036146.2,
XP_011240125.1,
NP_001303618.1,
XP_011240121.1,
XP_011240119.1,
XP_030098475.1,
XP_017177771.1,
XP_011240124.1,
XP_030098474.1,
XP_011240120.1
|
| Others |
UniRef100:
UniRef100_Q3UTN5,
UniRef100_Q32MS5,
UniRef100_Q9Z2E3
UniRef90:
UniRef90_Q9Z2E3
UniRef50:
UniRef50_Q76MJ5
UniGene:
Mm.20452
CCDS:
CCDS21813.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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