| Type | Description |
|---|---|
| Definition | serine palmitoyltransferase, long chain base subunit 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-07-08 12:06:00 | mice with an adipocyte-specific deletion of Sptlc1 show that de novo sphingolipid biosynthesis is required for adipocyte cell viability and normal metabolic function and that reduced de novo sphingolipid biosynthesis within adipocytes is associated with adipocyte death, adipose tissue remodeling, and metabolic dysfunction | 28100772 |
| 2015-10-24 10:46:00 | Data suggest that overexpression of serine palmitoyltransferase (Sptlc1, serine palmitoyltransferase long chain base subunit 1) to elevate de novo sphingolipid biosynthesis induces autophagy in the liver. | 25332431 |
| 2010-01-21 00:00:00 | Both Sptlc1 and Sptlc2 interactions are necessary for Serine palmitoyl-CoA transferase (SPT) activity in vivo and SPT activity directly influences plasma sphingolipid levels | 16216550 |
| 2010-01-21 00:00:00 | Physical interaction of ABCA1 and SPTLC1 results in reduction of ABCA1 activity and that inhibition of this interaction produces enhanced cholesterol efflux. | 18484747 |
| 2010-01-21 00:00:00 | Sptlc1 deficient mice absorb less cholesterol. | 19416652 |
| Type | IDs |
|---|---|
| Synonymous | AW552086, C77762, E030036H05, Lcb1, SPT1 |
| Gene |
UniProtKB-ID:
SPTC1_MOUSE
UniprotKB:
O35704
UniParc:
UPI000000B9B7
EMBL:
AK084391,
AK079578,
AK084445,
AF003823,
X95641,
BC046323,
AK053207
Ensembl:
ENSMUSG00000021468
KO:
mmu:268656
|
| Nucleutide sequences |
EMBL-CDS:
BAC39185.1,
CAA64897.1,
BAC39172.1,
BAC37690.1,
AAH46323.1,
AAC02264.1,
BAC35310.1
Ensembl_TRS:
ENSMUST00000021920
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000021920
RefSeq:
XP_006516990.1,
NP_033295.2
|
| Others |
UniRef100:
UniRef100_O35704
UniRef90:
UniRef90_O35704
UniRef50:
UniRef50_O35704
UniGene:
Mm.240336
CCDS:
CCDS26521.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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