| Type | Description |
|---|---|
| Definition | essential meiotic structure-specific endonuclease 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-09 11:37:00 | Double mutant mice homozygous for the Mlh3DN/DN and Mus81-/- mutations show losses in chiasmata close to those observed in Mlh3-/- males, indicating that the MUS81-EME1-regulated crossover pathway can only partially account for the increased residual chiasmata in Mlh3DN/DN spermatocytes | 31170160 |
| 2016-12-31 10:37:00 | Study found that a Gen1 mutation alone did not affect DNA repair or meiotic recombination in mice; it caused synthetic lethality when combined with Eme1 mutations at an early embryonic stage. Also, combination of Gen1 and Eme1 mutations makes embryonic fibroblasts more sensitive to DNA damage & mice less capable of meiotic recombination. These results indicate that Gen1 and Eme1 are functionally redundant in mice. | 27383418 |
| 2014-01-18 10:44:00 | indicate that SLX1 and MUS81-EME1 nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4. | 24076219 |
| 2010-01-21 00:00:00 | These findings link Eme1 with the replication-associated chromatin modifier functions of Np95 in the cellular response to DNA damage. | 18692478 |
| 2010-01-21 00:00:00 | Mus81-Eme1- and Rad54-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway | 17036055 |
| Type | IDs |
|---|---|
| Synonymous | 6820428D13 |
| Gene |
UniProtKB-ID:
EME1_MOUSE
UniprotKB:
Q8BJW7
UniParc:
UPI00000EB651
EMBL:
AL645764,
BC089459,
AK078516
Ensembl:
ENSMUSG00000039055
KO:
mmu:268465
|
| Nucleutide sequences |
EMBL-CDS:
AAH89459.1,
BAC37318.1
Ensembl_TRS:
ENSMUST00000039949
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000036361
RefSeq:
XP_011247347.1,
XP_030101897.1,
NP_001366617.1,
NP_808420.1
|
| Others |
UniRef100:
UniRef100_Q8BJW7
UniRef90:
UniRef90_Q8BJW7
UniRef50:
UniRef50_Q96AY2
UniGene:
Mm.358937
CCDS:
CCDS25262.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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