| Type | Description |
|---|---|
| Definition | GDNF family receptor alpha 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-02 10:52:00 | We have reconstituted the complete extracellular region of the RET signaling complex together with Neurturin (NRTN) and GFRalpha2 and determined its structure at 5.7-A resolution by cryo-EM. The proteins form an assembly through RET-GFRalpha2 and RET-NRTN interfaces. | 31392261 |
| 2019-11-09 11:26:00 | GFRA2 was upregulated in human neuroblastoma cells and tissues, and promoted neuroblastoma cell proliferation through interacting with the tumor suppressor PTEN. | 30722993 |
| 2019-03-23 11:05:00 | A novel genome-wide significant locus at GFRA2 on chromosome 8p21.3 was identified to be associated with disease risk, and expression analyses showed that the risk-associated allele at rs36196656 decreased GFRA2 mRNA concentrations in GFRA2 tissue. | 29724592 |
| 2018-12-22 10:44:00 | biophysical results show that the relative concentration of GFRa2 on cell surfaces can affect the functional affinity of NRTN through avidity effects. | 29414779 |
| 2017-11-25 15:21:00 | The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase. | 27396331 |
| Type | IDs |
|---|---|
| Synonymous | GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2 |
| Gene |
UniProtKB-ID:
GFRA2_HUMAN
UniprotKB:
O00451
UniParc:
UPI000000D9B1,
UPI0000E0B44C,
UPI0000E0B448
EMBL:
BC041688,
AP008236,
AC129925,
AF002700,
AY941828,
AY326396,
AC105186,
U93703,
U97145
Ensembl:
ENSG00000168546
KO:
hsa:2675
|
| Nucleutide sequences |
EMBL-CDS:
AAX46325.1,
AAP88378.1,
AAC52036.1,
AAH41688.1,
AAB61922.1,
AAC51647.1
Ensembl_TRS:
ENST00000518077,
ENST00000524240,
ENST00000517892,
ENST00000517328
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000429979,
ENSP00000429445,
ENSP00000429206,
ENSP00000428518
RefSeq:
NP_001158511.1,
XP_024302895.1,
NP_001486.4,
NP_001158510.1,
XP_011542786.1,
XP_006716390.1
|
| Others |
UniRef100:
UniRef100_O00451
UniRef90:
UniRef90_O00451
UniRef50:
UniRef50_O00451
UniGene:
Hs.441202
CCDS:
CCDS47816.1,
CCDS55208.1,
CCDS55207.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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