| Type | Description |
|---|---|
| Definition | interleukin-1 receptor-associated kinase 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:02:00 | IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colorectal cancer. | 31527315 |
| 2019-08-17 10:45:00 | Pharmacological inhibition or siRNA mediated knockdown of IRAK1/4 attenuated Nod1-mediated activation of NF-kappaB, JNK, and the expression of proinflammatory cytokines. These results reveal that Nod1-mediated lipolysis promoted accumulation of DAG, which engaged and IRAK1/4 to augment inflammation in 3T3-L1 adipocytes. | 30391544 |
| 2019-05-25 10:10:00 | IRAK4 kinase activity is prerequisite for regulating innate immunity during infections with intracellular bacteria. The loss of IRAK4 kinase activity underlies deficient cytokine and microbicidal responses during infection with intracellular bacteria L. monocytogenes or M. smegmatis via impaired activation of IRAK1, MAPKs, and NF-kappaB but increases bacterial burdens, correlating with decreased induction of NO. | 29749650 |
| 2019-03-09 12:46:00 | our results indicate that IRAK4 has a critical scaffold function in myddosome formation and that its kinase activity is dispensable for myddosome assembly and activation of the NF-kappaB and MAPK pathways but is essential for MyD88-dependent production of inflammatory cytokines. Our findings suggest that the scaffold function of IRAK4 may be an attractive target for treating inflammatory and autoimmune diseases. | 30076215 |
| 2017-11-18 13:08:00 | AMPK activation inhibited IL-1beta-stimulated CXCL10 secretion, associated with reduced interleukin-1 receptor associated kinase-4 (IRAK4) phosphorylation. | 27840174 |
| Type | IDs |
|---|---|
| Synonymous | 8430405M07Rik, 9330209D03Rik, IRAK-4, NY-REN-64 |
| Gene |
UniProtKB-ID:
IRAK4_MOUSE
UniprotKB:
Q8R4K2
UniParc:
UPI00000285C7
EMBL:
AF445803,
AK028837,
BC051676
Ensembl:
ENSMUSG00000059883
KO:
mmu:266632
|
| Nucleutide sequences |
EMBL-CDS:
AAH51676.1,
AAM15773.1,
BAC26146.1
Ensembl_TRS:
ENSMUST00000074936
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000074471
RefSeq:
NP_084202.2,
XP_011243947.1
|
| Others |
UniRef100:
UniRef100_Q8R4K2
UniRef90:
UniRef90_Q8R4K2
UniRef50:
UniRef50_Q9NWZ3
UniGene:
Mm.422858
CCDS:
CCDS27772.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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