PF3D7_0810800 - hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase-BMKCloudï½ç¾è¿å®¢äº

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2655294 PF3D7_0810800

基因描述

Type	Description
Definition	hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase

研究结论

Date	Results	Publications
2018-03-31 10:04:00	Polymorphism in dihydrofolate reductase and dihydropteroate synthetase genes after five years of artemisinin combination therapy (ACT) implementation in urban India has been reported.	28533179
2016-01-30 11:07:00	PCR positive samples showed a high prevalence of dhfr triple (Asn-108 + Arg-59 + Ile-59) mutant (68%) and dhps double (Gly -437 + Glu-540) mutant (21%). The quintuple haplotype was found in 17% with 2 samples with an additional Gly-581 mutation.	25943379
2015-06-20 12:22:00	The low ineffectiveness of sulphadoxine-pyrimethamine was associated with two novel mutations of pfdhps, K540T and I588F.	25187019
2015-04-18 11:18:00	Plasmodium vivax and P. falciparum dhfr and dhps genes were sequenced to detect nucleotide polymorphisms in malaria patients before introduction of chloroquine and sulphadoxine-pyrimethamine.	25311473
2014-08-23 11:50:00	Report on the mutational analysis of pfdhfr and pfdhps in single Plasmodium falciparum infection isolates from the interior division of Sabah, Malaysian Borneo.	24321120

名称对应

Type	IDs
Synonymous	PF08_0095
Gene	UniProtKB-ID: Q8IAU3_PLAF7 UniprotKB: Q8IAU3 UniParc: UPI00000858DF EMBL: AL844507 EnsemblGenome: PF3D7_0810800 KO: pfa:PF3D7_0810800
Nucleutide sequences	EMBL-CDS: CAD51267.1 Gene_ORFName: PF3D7_0810800
Protein sequencees	RefSeq: XP_001349418.1
Others	UniRef100: UniRef100_A0A2I0BXA0 UniRef90: UniRef90_A0A060RWA0 UniRef50: UniRef50_A0A060RWA0

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
28533179	Polymorphisms in pfdhfr and pfdhps genes after five years of artemisinin combination therapy (ACT) implementation from urban Kolkata, India. Infect Genet Evol Moytrey Chatterjee , Swagata Ganguly , Pabitra Saha , Subhasish K Guha , Ardhendu Kumar Maji	2017-09-01	-
25943379	High prevalence of dhfr and dhps molecular markers in Plasmodium falciparum in pregnant women of Nchelenge district, Northern Zambia. Malar. J. Mwiche N P Siame , Sungano Mharakurwa , James Chipeta , Philip Thuma , Charles Michelo	2015-01-01	DHPS
25311473	Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy. Malar J Karryn J Gresty , Karen-Ann Gray , Albino Bobogare , Lyndes Wini , George Taleo , Jeffrey Hii , Qin Cheng , Norman C Waters	2014-10-14	-
25187019	Two novel mutations of pfdhps K540T and I588F, affecting sulphadoxine-pyrimethamine-resistant response in uncomplicated falciparum malaria at Banjar district, South Kalimantan Province, Indonesia. Malar. J. Sukmawati Basuki , Fitriah , Sugeng Riyanto , Budiono , Yoes P Dachlan , Haruki Uemura	2014-01-01	DHPS
24321120	Mutational analysis of Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in the interior division of Sabah, Malaysia. Malar. J. Tiek Ying Lau , Mersumpin Sylvi , Timothy William	2013-01-01	DHPS, DHFR-TS
22909027	Novel quadruple mutations in dihydropteroate synthase genes of Plasmodium falciparum in West Bengal, India. Trop. Med. Int. Health Sabyasachi Das , Subhankari P Chakraborty , Satyajit Tripathy , Amiyakumar Hati , Somenath Roy	2012-11-01	DHPS
15642967	Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda. Am. J. Trop. Med. Hyg. Grant Dorsey , Christian Dokomajilar , Moses Kiggundu , Sarah G Staedke , Moses R Kamya , Philip J Rosenthal	2004-12-01	DHPS
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature N Hall , A Pain , M Berriman , C Churcher , B Harris , D Harris , K Mungall , S Bowman , R Atkin , S Baker , A Barron , K Brooks , C O Buckee , C Burrows , I Cherevach , C Chillingworth , T Chillingworth , Z Christodoulou , L Clark , R Clark , C Corton , A Cronin , R Davies , P Davis , P Dear , F Dearden , J Doggett , T Feltwell , A Goble , I Goodhead , R Gwilliam , N Hamlin , Z Hance , D Harper , H Hauser , T Hornsby , S Holroyd , P Horrocks , S Humphray , K Jagels , K D James , D Johnson , A Kerhornou , A Knights , B Konfortov , S Kyes , N Larke , D Lawson , N Lennard , A Line , M Maddison , J McLean , P Mooney , S Moule , L Murphy , K Oliver , D Ormond , C Price , M A Quail , E Rabbinowitsch , M-A Rajandream , S Rutter , K M Rutherford , M Sanders , M Simmonds , K Seeger , S Sharp , R Smith , R Squares , S Squares , K Stevens , K Taylor , A Tivey , L Unwin , S Whitehead , J Woodward , J E Sulston , A Craig , C Newbold , B G Barrell	2002-10-03	MAL7P1.110, MAL7P1.113, MAL7P1.104, MAL7P1.93, MAL7P1.94, PF07_0005, PF07_0014, MAL7P1.162, MAL7P1.164, MAL7P1.4, MAL7P1.69, MAL7P1.73, MAL7P1.147, MAL7P1.150, MAL7P1.151, MAL7P1.161, MAL7P1.75, MAL7P1.81, MAL7P1.86, PF07_0021, PF07_0023, PF07_0027, PF07_0040, MAL7P1.137, MAL7P1.139, MAL7P1.145, PF07_0046, PF07_0047, PF07_0054, PF07_0057, PF07_0059, PF07_0062, PF07_0065, PF07_0070, PF07_0071, PfCDPK4, PF07_0073, PF07_0079, PF07_0080, PF07_0085, PF07_0086, PF07_0088, PF07_0091, PF07_0098, MAL7P1.130, PF07_0103, PF07_0105, PF07_0112, PF07_0115, PF07_0117, PF07_0123, MAL7P1.118, MAL7P1.12, MAL7P1.122, MAL7P1.20, PfCRT, MAL7P1.37, MAL7P1.38, MAL8P1.13, MAL8P1.131, MAL8P1.23, MAL8P1.12, MAL8P1.125, MAL8P1.128, MAL8P1.110, PF08_0055, PF08_0056, PF08_0059, PF08_0069, FeSOD, PF08_0075, PF08_0076, PF08_0084, PF08_0085, PF08_0096, PF08_0108, PF08_0126, PF08_0129, PF08_0132, PF08_0136b, MAL8P1.48, MAL8P1.51, MAL8P1.37, MAL8P1.40, MAL8P1.43, MAL8P1.108, MAL8P1.140, MAL8P1.3, MAL8P1.31, MAL8P1.32, MAL8P1.33, MAL8P1.76, MAL8P1.78, MAL8P1.83, MAL8P1.9, PF08_0006, PF08_0009, PF08_0011, PF08_0014
7925353	Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur. J. Biochem. D R Brooks , P Wang , M Read , W M Watkins , P F Sims , J E Hyde	1994-09-01	-
20890550	[Point mutations in dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum from three endemic malaria regions in Colombia]. Biomedica John Alexander Galindo , Fabio AnÃbal Cristiano , AngÃ©lica Knudson , RubÃ©n Santiago Nicholls , Angela Patricia Guerra	1700-01-01	DHPS

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