| Type | Description |
|---|---|
| Definition | erythrocyte binding antigen-175 |
| Date | Results | Publications |
|---|---|---|
| 2018-01-13 10:35:00 | The authors show that Plasmodium falciparum EBA-175 mediates substantial changes in the deformability of erythrocytes by binding to glycophorin A and activating a phosphorylation cascade that includes erythrocyte cytoskeletal proteins resulting in changes in the viscoelastic properties of the host cell. | 28226242 |
| 2016-02-06 11:38:00 | Clinical falciparum malaria isolates from Thailand were used to study the genetic variation of EBA-175 in P. falciparum through dispersal of humans out of Africa. | 26231699 |
| 2015-05-30 10:23:00 | PfEBA-175 engages multiple glycans of GpA encoded by exon 3 and that the presentation of glycans is likely required for high-avidity binding. | 25205096 |
| 2014-01-25 12:18:00 | These data demonstrate the importance of PfEBA175 regions other than the DBL domains in the interaction with GYPA and merit their inclusion in an EBA175-based vaccine. | 24043627 |
| 2013-12-14 10:47:00 | Structural and functional basis for inhibition of erythrocyte invasion by antibodies that target Plasmodium falciparum EBA-175. | 23717209 |
| Type | IDs |
|---|---|
| Synonymous | MAL7P1.176 |
| Gene |
UniProtKB-ID:
Q8IBE8_PLAF7
UniprotKB:
Q8IBE8
UniParc:
UPI0001982057
EMBL:
AL844506
EnsemblGenome:
PF3D7_0731500
KO:
pfa:PF3D7_0731500
|
| Nucleutide sequences |
EMBL-CDS:
CAD51055.2
Gene_ORFName:
PF3D7_0731500
|
| Protein sequencees |
RefSeq:
XP_001349207.2
|
| Others |
UniRef100:
UniRef100_W7JW35
UniRef90:
UniRef90_W7JW35
UniRef50:
UniRef50_P19214
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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