| Type | Description |
|---|---|
| Definition | thioredoxin reductase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 12:28:00 | Study identified a causal molecular mechanism that reflects diminished dosage of a single 22q11 gene-the mitochondrial enzyme thioredoxin-reductase 2 (Txnrd2)-essential for catabolism of reactive oxygen species underlies reduced long-distance projections, limited axon and dendrite growth, and disrupted mitochondrial and synaptic integrity in layer 2/3 in DiGeorge syndrome. | 31079872 |
| 2019-10-05 11:52:00 | This was accompanied by decreased NADPH redox state and decreased activity of TXNRD2 in the mitochondria of the HEI-OC1 cells. Therefore, IDH2 functions as the principal source of NADPH for the mitochondrial thioredoxin antioxidant defense and plays an essential role in protecting hair cells and neurons against oxidative stress in the cochlea of male mice. | 29567975 |
| 2017-06-24 11:03:00 | Maintenance of mitochondrial via Txnrd2 in endothelial cells is necessary for an intact vascular homeostasis and remodeling. Txnrd2 plays a vitally important role in balancing mitochondrial duanyu1670 production in the endothelium. | 27386940 |
| 2016-04-23 10:43:00 | Suggest role for Txnrd2 in sustaining heart function during aging and suggest that Txnrd2 may be a modifier of heart failure. | 26199228 |
| 2015-11-14 11:00:00 | Regulatory link was discovered between mitochondrial Txnrd and the JNK-PHD2-Hif-1alpha axis, which highlights how the loss of Txnrd2 and the resulting altered mitochondrial redox balance impairs tumor growth as well as tumor-related angiogenesis. | 25647640 |
| Type | IDs |
|---|---|
| Synonymous | AA118373, ESTM573010, TGR, Tr3, Trxr2, Trxrd2 |
| Gene |
UniProtKB-ID:
TRXR2_MOUSE
UniprotKB:
Q9JLT4
UniParc:
UPI00004CEC54,
UPI0001642909,
UPI0001642908,
UPI0000029783
EMBL:
AF136399,
AB027566,
AF171053,
BC013688,
AF414356,
AF414357,
AF414359,
BC052157,
AF414358,
AF412308
KO:
mmu:26462
|
| Nucleutide sequences |
EMBL-CDS:
BAA86986.2,
AAF03359.1,
AAH52157.3,
AAH13688.1,
AAQ03230.1,
AAD51323.1,
AAL90457.1
|
| Protein sequencees |
RefSeq:
NP_001340072.1,
NP_038739.2
|
| Others |
UniRef100:
UniRef100_Q9JLT4
UniRef90:
UniRef90_Q9Z0J5-2
UniRef50:
UniRef50_Q9Z0J5-2
UniGene:
Mm.390906
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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