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26432 Plod2

26432

Plod2

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

protein-coding

Mus musculus

基因描述

Type Description
Definition procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

研究结论

Date Results Publications
2020-04-11 10:28:00 Homozygous lysyl hydroxylase 2 knockout (LH2(-/-)) embryos failed to develop normally and died at early embryonic stage E10.5 with abnormal common ventricle in a heart, i.e., an insufficient wall, a thin ventricular wall, and loosely packed cells. 30905411
2019-11-02 11:22:00 Data suggest a pro-metastatic GATA3 (GATA3)- lysyl hydroxylases (LHs) axis for lung cancer, supporting the notion that targeting LHs may be useful for treating lung cancer. 30093726
2018-12-01 11:17:00 FKBP65 regulates LH2-mediated collagen cross-linking. 28378777
2017-05-27 12:06:00 The finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2 functions solely on the endoplasmic reticulum and could also have important implications for cancer biology. 27803159
2013-07-27 10:48:00 Authors propose that lysyl hydroxylase 2, and the subsequent increase in pyridinoline cross-links, is responsible for the persistent fibrosis in experimental osteoarthritis. 23069856

名称对应

Type IDs
Synonymous D530025C14Rik, LH2, Plod-2
Gene
UniProtKB-ID: PLOD2_MOUSE, E9Q718_MOUSE
UniprotKB: Q9R0B9, E9Q718
UniParc: UPI0000023A77, UPI0001889E15
EMBL: AC165156, BC021352, AF080572
Ensembl: ENSMUSG00000032374
KO: mmu:26432
Nucleutide sequences
EMBL-CDS: AAD53987.1, AAH21352.1
Ensembl_TRS: ENSMUST00000070522, ENSMUST00000160359
Protein sequencees
Ensembl_PRO: ENSMUSP00000068611, ENSMUSP00000125373
RefSeq: XP_036010914.1, NP_036091.2, XP_030100253.1, NP_001136388.1, XP_036010915.1
Others
UniRef100: UniRef100_E9Q718, UniRef100_Q9R0B9
UniRef90: UniRef90_Q9R0B9
UniRef50: UniRef50_O00469
UniGene: Mm.79983
CCDS: CCDS23408.1

全选

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