| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase 10 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 11:36:00 | JNK3 deficiency leads to upregulation of growth factors such as Vegfa, Pdgfb, Pgf, Hbegf and Tgfb3 in ischemic muscle by activation of the transcription factors Egr1/Creb1. | 31530804 |
| 2019-12-21 12:06:00 | JNK isoforms are involved in the adult neurogenesis control. | 30685843 |
| 2019-09-14 10:20:00 | Together these data indicate that ONA induces APP expression and that gamma-secretase cleavage of APP releases AICD, which upregulates JNK3 leading to RGC death. This pathway may be a novel target for neuronal protection in optic neuropathies and other forms of neurotrauma. | 29238071 |
| 2019-02-09 10:03:00 | JNK1 and/or JNK3 are promising targets for the prevention of cell death and inflammation during epileptogenesis. | 28664455 |
| 2017-05-27 10:26:00 | Conversely, treatment with LY294002 (a selective inhibitor of Akt1) reversed the effects of quercetin. In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt signaling pathway. We believe that quercetin might prove to be a useful therapeutic component in treating cerebral I/R diseases in the near future. | 27450812 |
| Type | IDs |
|---|---|
| Synonymous | C230008H04Rik, JNK3, JNK3B1, JNK3B2, SAPK(beta), Serk2, p493F12, p54bSAPK |
| Gene |
UniProtKB-ID:
MK10_MOUSE,
Q78GB8_MOUSE,
Q8C9D4_MOUSE,
Q80W82_MOUSE,
Q3TQZ7_MOUSE,
Q80W81_MOUSE,
Q80W80_MOUSE,
A0A5F8MP75_MOUSE
UniprotKB:
Q61831,
Q78GB8,
Q8C9D4,
Q80W82,
Q3TQZ7,
Q80W81,
Q80W80,
A0A5F8MP75
UniParc:
UPI000000BA50,
UPI000019A1E2,
UPI000733F001,
UPI00005B1F3B,
UPI000019A1E3,
UPI00000290A7,
UPI00000336D5,
UPI000002785D,
UPI000019A1E1
EMBL:
AB096079,
BC046625,
AC160244,
AB005665,
AC123664,
AB096076,
AC137121,
AK163206,
AC125252,
L35236,
AB096078,
AK042368,
AB096077
Ensembl:
ENSMUSG00000046709
KO:
mmu:26414
|
| Nucleutide sequences |
EMBL-CDS:
AAB37741.1,
BAA85877.1,
AAH46625.2,
BAC76451.1,
BAC31240.1,
BAC76450.1,
BAE37234.1,
BAC76452.1,
BAC76453.1
Ensembl_TRS:
ENSMUST00000112847,
ENSMUST00000170792,
ENSMUST00000112846,
ENSMUST00000086854,
ENSMUST00000238446
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000108468,
ENSMUSP00000127193,
ENSMUSP00000108467,
ENSMUSP00000084065,
ENSMUSP00000158744
RefSeq:
XP_017176378.1,
NP_033184.2,
XP_030110378.1,
XP_017176380.1,
NP_001297615.1,
XP_017176375.1,
XP_006535013.1,
XP_030110376.1,
NP_001297614.1,
XP_017176377.1,
XP_011247752.1,
NP_001075036.1,
NP_001305031.1,
XP_030110379.1,
NP_001305060.1,
NP_001297612.1,
XP_017176379.1
|
| Others |
UniRef100:
UniRef100_A0A5F8MP75,
UniRef100_E9QN59,
UniRef100_A0A286YES0,
UniRef100_Q80W82,
UniRef100_Q80W80,
UniRef100_Q80W81,
UniRef100_Q61831
UniRef90:
UniRef90_Q61831-2,
UniRef90_P53779,
UniRef90_E9QN59,
UniRef90_P53779-2
UniRef50:
UniRef50_P49185,
UniRef50_P45984,
UniRef50_P53779,
UniRef50_P53779-2
UniGene:
Mm.39253,
Mm.472459
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员