| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase kinase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 10:54:00 | Results identify the importance of HPK1 kinase activity in the negative regulation of CD8 effector functions. | 30282040 |
| 2019-11-30 12:13:00 | data provide novel findings that HKP1 kinase activity is critical in conferring suppressive functions of HPK1 in a wide range of immune cells including CD4+, CD8+, DC, NK to Tregs, and inactivation of kinase domain was sufficient to elicit robust anti-tumor immune responses. | 30913212 |
| 2013-07-06 12:33:00 | Introduction of three 4-R-hydroxyproline residues stabilizes the SH3m-cortactin binding of HPK1 peptide. | 22976002 |
| 2012-09-22 11:21:00 | a novel negative feedback regulation of BCR signaling by HPK1-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK | 22334673 |
| 2011-02-26 11:19:00 | HPK1 associates with SKAP1 to negatively regulate Rap1-mediated B-lymphocyte adhesion. | 20824186 |
| Type | IDs |
|---|---|
| Synonymous | Hpk1, mHPK1 |
| Gene |
UniProtKB-ID:
M4K1_MOUSE
UniprotKB:
P70218
UniParc:
UPI0000029FC3
EMBL:
BC005433,
Y09010,
BC024832
Ensembl:
ENSMUSG00000037337
KO:
mmu:26411
|
| Nucleutide sequences |
EMBL-CDS:
AAH05433.1,
AAH24832.1,
CAA70213.1
Ensembl_TRS:
ENSMUST00000085835
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000082995
RefSeq:
XP_006540060.1,
XP_006540058.1,
NP_032305.2,
XP_006540063.1,
NP_001341983.1,
XP_006540061.1,
XP_017177769.1,
XP_006540059.1
|
| Others |
UniRef100:
UniRef100_P70218
UniRef90:
UniRef90_P70218
UniRef50:
UniRef50_Q92918
UniGene:
Mm.148278
CCDS:
CCDS39865.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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