| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase 8 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:00:00 | Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells. | 31481966 |
| 2020-05-23 11:14:00 | promotes both liver and systemic metabolic disturbances by specifically increasing MKK7-JNK activation | 29381809 |
| 2019-06-08 12:24:00 | Our study demonstrates that Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein targets the TPL2 signalling pathway to induce immune-suppressive IL-10 cytokine production as a means to dampen the host defence and promote viral pathogenesis. | 30617349 |
| 2019-03-09 11:11:00 | The authors found that TPL2 was significantly activated in human and mouse intestinal tissues upon Clostridium difficile toxin exposure or infection. They further demonstrated that TPL2 knockout mice were significantly more resistant to infection than wild-type mice, with significantly reduced production of TNF-alpha, IL-6, IL-1beta, KC, and myeloperoxidase in the ceca and colons of TPL2-knockout mice. | 29844241 |
| 2019-01-19 10:47:00 | Map3k8 activity controls the massive production of neutrophils in LPS-induced emergency granulopoiesis. Map3k8 regulates LPS-induced G-CSF production, which upregulates C/EBPbeta expression in immature neutrophils to trigger their amplification. | 28694430 |
| Type | IDs |
|---|---|
| Synonymous | Cot, Cot/Tpl2, Est, Estf, Tpl-2, Tpl2, c-COT |
| Gene |
UniProtKB-ID:
M3K8_MOUSE,
Q3UEB8_MOUSE
UniprotKB:
Q07174,
Q3UEB8
UniParc:
UPI000002797E
EMBL:
AK140334,
AK149846,
BC125286,
AK149624,
D13759,
BC137922
Ensembl:
ENSMUSG00000024235
KO:
mmu:26410
|
| Nucleutide sequences |
EMBL-CDS:
BAA02905.1,
AAI37923.1,
BAE24343.1,
BAE29118.1,
BAE28993.1,
AAI25287.1
Ensembl_TRS:
ENSMUST00000025078
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000025078
RefSeq:
XP_006526007.1,
XP_036017050.1,
NP_031772.1,
XP_036017051.1
|
| Others |
UniRef100:
UniRef100_Q07174
UniRef90:
UniRef90_P41279
UniRef50:
UniRef50_P41279
UniGene:
Mm.3275
CCDS:
CCDS29036.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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