| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase 12 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:34:00 | Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions. | 32659913 |
| 2020-06-27 12:15:00 | Study shows that dual leucine zipper kinase inhibition preserves neuronal network connectivity. | 31164177 |
| 2020-01-11 12:20:00 | Using a sensory neuron-conditional DLK knockout mouse model, we show a time course for the dependency of gene expression changes on the DLK pathway after sciatic nerve injury. | 30735704 |
| 2019-03-23 10:19:00 | DLK is required for mechanical allodynia and microgliosis after nerve injury by controling a transcriptional program in somatosensory neurons regulating the expression of numerous genes implicated in pain pathogenesis, including Csf1. | 29968565 |
| 2018-05-05 12:13:00 | These findings demonstrate that pathological activation of DLK is a conserved mechanism that regulates neurodegeneration. | 28814543 |
| Type | IDs |
|---|---|
| Synonymous | DLK, MUK, Zpk |
| Gene |
UniProtKB-ID:
M3K12_MOUSE
UniprotKB:
Q60700
UniParc:
UPI00000220B8
EMBL:
AK034374,
BC057572,
AK166435,
BC047158,
U23789,
AK081623,
U14636,
AK029882
Ensembl:
ENSMUSG00000023050
KO:
mmu:26404
|
| Nucleutide sequences |
EMBL-CDS:
AAA57280.1,
AAH57572.1,
BAC28689.1,
BAC38274.1,
AAB17123.1,
BAC26658.1,
AAH47158.1,
BAE38775.1
Ensembl_TRS:
ENSMUST00000169377,
ENSMUST00000171565,
ENSMUST00000023812
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000023812,
ENSMUSP00000133209,
ENSMUSP00000127629
RefSeq:
XP_030104450.1,
XP_036015323.1,
XP_006521076.1,
XP_017172114.1,
NP_001157115.1,
XP_030104449.1,
NP_001345773.1,
XP_017172113.1,
XP_030104451.1,
NP_033608.3
|
| Others |
UniRef100:
UniRef100_Q60700
UniRef90:
UniRef90_Q60700
UniRef50:
UniRef50_Q60700
UniGene:
Mm.172897,
Mm.236513
CCDS:
CCDS27885.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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