| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase 11 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:38:00 | Anthocyanins attenuate neuroinflammation through the suppression of MLK3 activation in a mouse model of perioperative neurocognitive disorders. | 31654642 |
| 2021-03-27 14:44:00 | Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload. | 32710001 |
| 2020-07-25 12:10:00 | Study identified that genetic loss/inhibition of a MLK3, increases CD8+ T cell cytotoxicity via inhibition of a prolyl isomerase, Ppia, and nuclear translocation of NFATc1. The MLK3 inhibitor increased the tumor infiltration of cytotoxic T cells in an immune-competent mouse model of breast cancer and increased the cytotoxic T cell population in pan T cells isolated from breast cancer patients with metastatic disease. | 32209667 |
| 2020-05-30 10:46:00 | This study is the first to identify GNAI2 as a promising target for prevention of hepatic I/R-induced injury and related liver diseases | 30840837 |
| 2019-11-16 12:06:00 | MLK3-/- mice exhibited baseline cardiac hypertrophy with preserved cardiac function. MLK3-/- mice subjected to chronic left ventricular pressure overload developed worsened cardiac dysfunction. | 30362822 |
| Type | IDs |
|---|---|
| Synonymous | 2610017K16Rik, Mlk3, PTK1, SPRK |
| Gene |
UniProtKB-ID:
M3K11_MOUSE
UniprotKB:
Q80XI6
UniParc:
UPI000000BB74
EMBL:
BC030928,
BC047152,
AF155142,
BC095963
Ensembl:
ENSMUSG00000004054
KO:
mmu:26403
|
| Nucleutide sequences |
EMBL-CDS:
AAH47152.1,
AAH30928.1,
AAF73281.1,
AAH95963.1
Ensembl_TRS:
ENSMUST00000004156
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000004156
RefSeq:
XP_006531816.1,
XP_036017492.1,
XP_030106812.1,
XP_006531815.1,
XP_030106813.1,
XP_030106811.1,
NP_071295.2
|
| Others |
UniRef100:
UniRef100_Q80XI6
UniRef90:
UniRef90_Q66HA1
UniRef50:
UniRef50_Q66HA1
UniGene:
Mm.185026
CCDS:
CCDS29476.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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