| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:22:00 | Astrocyte-Derived Exosomal microRNA miR-200a-3p Prevents MPP(+)-Induced Apoptotic Through Down-Regulation of MKK4. | 32016794 |
| 2019-12-14 11:43:00 | These results suggest that MKK4 and MKK7 may serve redundant and unique roles in molecular signaling important for retinal development and injury response following axonal insult. | 30367030 |
| 2018-04-14 11:24:00 | MKK4 is the major MAP2K, which activates JNK in acute liver injury. p38, the other downstream target of MKK4, does not contribute to liver injury from APAP or TNF/galactosamine. | 28661486 |
| 2017-08-26 12:49:00 | MKK4 activates non-canonical NFkappaB signaling by promoting NFkappaB2-p100 processing. | 28733031 |
| 2014-11-22 13:01:00 | Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 signaling associated with atrial remodeling and arrhythmogenesis with age. | 24721794 |
| Type | IDs |
|---|---|
| Synonymous | JNKK1, MAPKK 4, MEK4, MKK4, PRKMK4, Sek1, Serk1 |
| Gene |
UniProtKB-ID:
MP2K4_MOUSE,
Q8K2U0_MOUSE,
Q543X6_MOUSE
UniprotKB:
P47809,
Q8K2U0,
Q543X6
UniParc:
UPI00000E6C8F,
UPI0000003FFD
EMBL:
BC029833,
AK044698,
U18310,
AK036928,
AK044534
Ensembl:
ENSMUSG00000033352
KO:
mmu:26398
|
| Nucleutide sequences |
EMBL-CDS:
AAB81554.1,
AAH29833.1,
BAC31968.1,
BAC29642.1,
BAC32038.1
Ensembl_TRS:
ENSMUST00000046963
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000041282
RefSeq:
NP_001349668.1,
NP_001303297.1,
NP_001349669.1,
NP_033183.1,
XP_030101878.1,
NP_001303298.1,
XP_011247335.1,
NP_001303296.1
|
| Others |
UniRef100:
UniRef100_P47809,
UniRef100_Q8K2U0
UniRef90:
UniRef90_P47809,
UniRef90_Q8K2U0
UniRef50:
UniRef50_A5PJP8,
UniRef50_P45985
UniGene:
Mm.412922
CCDS:
CCDS24844.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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