| Type | Description |
|---|---|
| Definition | COP1, E3 ubiquitin ligase |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 12:41:00 | Mechanistically, cryptochromes inactivate Cop1 by interacting with Det1, a subunit of the mammalian CRL4(Cop1) complex that is not present in other CRL4s. Through this interaction, the ability of Cop1 to join the CRL4 complex is inhibited; therefore, its substrates accumulate. Thus, the interaction between cryptochromes and Det1 in mammals mirrors the interaction between cryptochromes and Cop1 in planta. | 31155351 |
| 2020-06-27 11:07:00 | Lipotoxicity led to up-regulation of COP1 at both the gene and protein levels. | 31125554 |
| 2017-08-19 10:42:00 | Prenatal inactivation of Rfwd2 gene in the lung epithelium led to a striking halt in branching morphogenesis shortly after secondary branch formation. | 27335464 |
| 2016-04-09 11:26:00 | Study shows that post-translational regulation of the transcription factors ETV1, ETV4, and ETV5 by the ubiquitin ligase COP1 (also called RFWD2) in beta cells is critical for insulin secretion. Mice lacking COP1 in beta cells developed diabetes due to insulin granule docking defects that were fully rescued by genetic deletion of Etv1, Etv4, and Etv5. | 26627735 |
| 2013-11-02 12:10:00 | These results indicate that COP1 and Trib1 act as an oncoprotein complex functioning upstream of C/EBPalpha, and its ligase activity is crucial for leukemogenesis. | 23884858 |
| Type | IDs |
|---|---|
| Synonymous | AI316802, C80879, Rfwd2 |
| Gene |
UniProtKB-ID:
COP1_MOUSE
UniprotKB:
Q9R1A8
UniParc:
UPI0000029412
EMBL:
BC082804,
AF151110
Ensembl:
ENSMUSG00000040782
KO:
mmu:26374
|
| Nucleutide sequences |
EMBL-CDS:
AAD51094.2,
AAH82804.1
Ensembl_TRS:
ENSMUST00000076894
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000076160
RefSeq:
XP_006496923.1,
NP_001347807.1,
NP_036061.1,
XP_030110257.1,
XP_030110256.1,
XP_030110253.1
|
| Others |
UniRef100:
UniRef100_Q9R1A8
UniRef90:
UniRef90_Q8NHY2
UniRef50:
UniRef50_Q8NHY2
UniGene:
Mm.328135
CCDS:
CCDS35745.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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