| Type | Description |
|---|---|
| Definition | TERF1 interacting nuclear factor 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:22:00 | TINF2 is a haploinsufficient tumor suppressor that limits telomere length. | 33258446 |
| 2021-01-09 13:33:00 | Acute depletion of telomerase components DKC1 and NOP10 induces oxidative stress and disrupts ribosomal biogenesis via NPM1 and activation of the P53 pathway. | 32910990 |
| 2020-06-20 11:20:00 | Authors found that TPP1(ACD) upon binding to TIN2 induces changes that expand TIN2 binding capacity, such that TIN2 can accommodate both TRF1 and TRF2 simultaneously. Authors suggest a molecular model that explains why ACD is essential for the stable formation of TRF1-TIN2-TRF2 core complex. | 31158366 |
| 2020-02-29 10:33:00 | All of the TIN2 isoforms stimulated telomerase to similar extents. Mutations in the TPP1 TEL patch abrogated this stimulation, suggesting that TIN2 functions with TPP1/POT1 to stimulate telomerase processivity. | 31383750 |
| 2019-08-10 12:54:00 | Loss of RNA-binding protein HuR facilitates cellular senescence through posttranscriptional regulation of TIN2 mRNA. | 29584879 |
| Type | IDs |
|---|---|
| Synonymous | DKCA3, TIN2 |
| Gene |
UniProtKB-ID:
TINF2_HUMAN
UniprotKB:
Q9BSI4
UniParc:
UPI000002B556,
UPI000002B557,
UPI0000136FAB
EMBL:
AK023166,
EU851975,
BC005030,
BC019343,
AF195512
Ensembl:
ENSG00000284915,
ENSG00000092330
KO:
hsa:26277
|
| Nucleutide sequences |
EMBL-CDS:
AAF18439.1,
BAB14440.1,
ACF17559.1,
AAH05030.1,
AAH19343.1
Ensembl_TRS:
ENST00000642983,
ENST00000267415,
ENST00000399423,
ENST00000646576
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000494089,
ENSP00000267415,
ENSP00000495019,
ENSP00000382350
RefSeq:
NP_001350597.1,
NP_036593.2,
NP_001092744.1,
XP_016876705.1,
XP_016876706.1,
XP_011534944.1
|
| Others |
UniRef100:
UniRef100_Q9BSI4
UniRef90:
UniRef90_Q9BSI4
UniRef50:
UniRef50_Q9BSI4
UniGene:
Hs.496191
CCDS:
CCDS41936.1,
CCDS41937.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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