| Type | Description |
|---|---|
| Definition | F-box protein 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 10:11:00 | FBXO3 potentiates vascular inflammation and atherosclerosis that can be effectively mitigated by a small molecule inhibitor. | 30448480 |
| 2019-03-23 12:10:00 | reveal that FBXO46 is a crucial proteasomal regulator of FBXO31 and thereby prevents senescence in normal growth conditions | 30171069 |
| 2017-06-24 12:28:00 | we report the X-ray structure of the human FBxo3 ApaG domain, residues 278-407, at 2.0 A resolution | 27010866 |
| 2017-05-13 22:22:00 | AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity. | 27365398 |
| 2015-05-30 12:14:00 | Fbxo3 promotes the proteasomal degradation of Smurf1. Fbxo3 promotes the poly-ubiquitination of Smurf1. | 25721664 |
| Type | IDs |
|---|---|
| Synonymous | FBA, FBX3 |
| Gene |
UniProtKB-ID:
FBX3_HUMAN,
Q49AF1_HUMAN
UniprotKB:
Q9UK99,
Q49AF1
UniParc:
UPI0000167B7A,
UPI000056F198,
UPI000000DB30,
UPI00004A2974
EMBL:
CH471064,
AL049629,
AK316286,
AK001943,
BC039291,
AK128454,
BC046110,
AC113192,
AL136625,
AF176702
Ensembl:
ENSG00000110429
KO:
hsa:26273
|
| Nucleutide sequences |
EMBL-CDS:
CAB66560.1,
BAA91991.1,
AAF03702.1,
EAW68188.1,
BAG54678.1,
EAW68189.1,
AAH46110.1,
EAW68186.1,
AAH39291.1,
BAH14657.1
Ensembl_TRS:
ENST00000265651,
ENST00000530401,
ENST00000448981,
ENST00000532057,
ENST00000531080
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000433781,
ENSP00000408836,
ENSP00000265651,
ENSP00000434001,
ENSP00000435165
RefSeq:
XP_011518283.1,
XP_011518282.1,
XP_016873022.1,
NP_036307.2,
XP_011518284.1,
NP_208385.1
|
| Others |
UniRef100:
UniRef100_Q9UK99
UniRef90:
UniRef90_Q9UK99
UniRef50:
UniRef50_Q9UK99
UniGene:
Hs.406787
CCDS:
CCDS44566.1,
CCDS7887.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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