| Type | Description |
|---|---|
| Definition | F-box protein 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-02 10:25:00 | We identified hyperphosphorylation of CDH1, but not pseudosubstrate inhibition by early mitotic inhibitor 1 (EMI1), as a major mechanism driving attenuated APC/C(CDH1) activity in the G1-phase of the cell cycle in cancer stem-like cells (CSC). | 31036696 |
| 2019-07-27 12:28:00 | Higher mRNA expression levels of FBXO1, FBXO31, SKP2, and FBXO5 were significantly associated with worse prognosis for breast cancer patients. (Review) | 30341246 |
| 2019-06-01 10:15:00 | A subset of BRCA1-deficient triple-negative breast cancer cells develop resistance to inhibitors by downregulating EMI1 and restoring RAD51-dependent HRR. Reconstitution of EMI1 expression reestablishes sensitivity both in cellular systems and in an orthotopic mouse model. | 30554948 |
| 2018-11-17 10:24:00 | demonstration using human cell models that cell-cycle commitment is mediated by an EMI1-APC/C(CDH1) dual-negative feedback switch, in which EMI1 is both a substrate and an inhibitor of APC/C(CDH1) | 29875408 |
| 2018-10-06 12:10:00 | Both isoforms of FBXO5 promoted the migration and osteogenic differentiation potential of human periodontal ligament stem cells. | 29850565 |
| Type | IDs |
|---|---|
| Synonymous | EMI1, FBX5, Fbxo31 |
| Gene |
UniProtKB-ID:
FBX5_HUMAN
UniprotKB:
Q9UKT4
UniParc:
UPI000012A585,
UPI000020D0DA
EMBL:
AK055221,
AL080276,
AF129535,
AY079515,
BC018905,
CH471051
Ensembl:
ENSG00000112029
KO:
hsa:26271
|
| Nucleutide sequences |
EMBL-CDS:
EAW47719.1,
BAG51487.1,
AAH18905.1,
AAL86610.1,
AAF04469.1
Ensembl_TRS:
ENST00000367241,
ENST00000229758
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000356210,
ENSP00000229758
RefSeq:
NP_001135994.1,
NP_036309.1
|
| Others |
UniRef100:
UniRef100_Q9UKT4
UniRef90:
UniRef90_Q9UKT4
UniRef50:
UniRef50_Q9UKT4
UniGene:
Hs.520506
CCDS:
CCDS47501.1,
CCDS5242.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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