| Type | Description |
|---|---|
| Definition | F-box and WD repeat domain containing 8 |
| Date | Results | Publications |
|---|---|---|
| 2019-01-19 10:26:00 | Frameshift mutation FBXW8 c.1312_1313delGT was considered functionally relevant and was investigated for its potential association with breast cancer risk through subsequent genotyping in two hospital-based breast cancer case-control series from Belarus and Germany, respectively, comprising a total of 2740 breast cancer cases and 2174 controls. | 29310837 |
| 2016-02-27 10:52:00 | FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated | 25790475 |
| 2014-11-08 11:14:00 | findings will shed light the role to mechanism of miR-218 in regulating JEG-3 cells proliferation via miR-218/Fbxw8 axis, and miR-218 may serve as a novel potential therapeutic target in human choriocarcinoma in the future | 24973709 |
| 2014-05-03 10:35:00 | CUL7/Fbxw8 ubiquitin ligase-mediated HPK1 degradation revealed a direct link and novel role of CUL7/Fbxw8 ubiquitin ligase in the MAPK pathway, which plays a critical role in cell proliferation and differentiation. | 24362026 |
| 2013-05-04 11:50:00 | Dysregulation of Cul7 and Fbxw8 expression might affect trophoblast turnover in intrauterine growth restriction. | 22524683 |
| Type | IDs |
|---|---|
| Synonymous | FBW6, FBW8, FBX29, FBXO29, FBXW6 |
| Gene |
UniProtKB-ID:
FBXW8_HUMAN
UniprotKB:
Q8N3Y1
UniParc:
UPI000019AB71,
UPI000019AB72
EMBL:
AF176707,
BC037296,
AC026368,
AC083806,
AC127164
Ensembl:
ENSG00000174989
KO:
hsa:26259
|
| Nucleutide sequences |
EMBL-CDS:
AAH37296.1,
AAF03129.1
Ensembl_TRS:
ENST00000652555,
ENST00000455858
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000498999,
ENSP00000389144
RefSeq:
XP_005253924.1,
XP_016874667.1,
XP_024304705.1,
NP_036306.1,
XP_016874666.1,
NP_699179.2,
XP_005253925.1,
XP_016874664.1,
XP_016874665.1
|
| Others |
UniRef100:
UniRef100_Q8N3Y1
UniRef90:
UniRef90_Q8N3Y1
UniRef50:
UniRef50_Q8N3Y1
UniGene:
Hs.624537,
Hs.696428
CCDS:
CCDS44988.1,
CCDS9182.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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