| Type | Description |
|---|---|
| Definition | opticin |
| Date | Results | Publications |
|---|---|---|
| 2012-11-17 10:47:00 | opticin binds to collagen and thereby competitively inhibits endothelial cell interactions with collagen via alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing the strong adhesion that is required for proangiogenic signaling via these integrins. | 22669977 |
| 2012-10-06 11:13:00 | VEGF and hypoxia could decrease opticin protein levels in the human retinal pigment epithelium secretome, and that opticin may be an enzymatic substrate for MMP-2. | 22534113 |
| 2010-04-07 21:39:00 | Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | 20201926 |
| 2010-01-21 00:00:00 | OPTC is a candidate gene for primary open-angle glaucoma | 17359525 |
| 2010-01-21 00:00:00 | OPTC and EPYC are unlikely to play a major role in high myopia. | 19844586 |
| Type | IDs |
|---|---|
| Synonymous | OPT |
| Gene |
UniProtKB-ID:
OPT_HUMAN
UniprotKB:
Q9UBM4
UniParc:
UPI00000015D9
EMBL:
AL391817,
BC074943,
AY077681,
AF161702,
BC074942,
CH471067,
AJ133790
Ensembl:
ENSG00000188770
KO:
hsa:26254
|
| Nucleutide sequences |
EMBL-CDS:
EAW91482.1,
AAH74942.1,
CAB53459.1,
AAH74943.1,
AAD45900.1,
AAL78286.1
Ensembl_TRS:
ENST00000367222
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000356191
RefSeq:
XP_011507708.1,
NP_055174.1
|
| Others |
UniRef100:
UniRef100_Q9UBM4
UniRef90:
UniRef90_Q9UBM4
UniRef50:
UniRef50_Q9UBM4
UniGene:
Hs.632468
CCDS:
CCDS1439.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 23319000 |
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Mol. Psychiatry J J Luykx , S C Bakker , E Lentjes , M Neeleman , E Strengman , L Mentink , J DeYoung , S de Jong , J H Sul , E Eskin , K van Eijk , J van Setten , J E Buizer-Voskamp , R M Cantor , A Lu , M van Amerongen , E P A van Dongen , P Keijzers , T Kappen , P Borgdorff , P Bruins , E M Derks , R S Kahn , R A Ophoff |
2014-02-01 |
NR2E3,
HGC6.3,
MIR4789,
TRAP1,
ISX-AS1,
LOC101927056,
LOC101928354,
LOC101928516,
NCOA2,
RAB10,
CSMD2,
C10orf90,
SENP8,
COL4A3,
C2orf50,
CREBBP,
VENTXP1,
CLEC14A,
GRAMD2,
EMP2,
ERG,
SMG6,
KIF13B,
NAALADL2,
OPTC,
RNU6-6P,
RNU6-1,
FLJ33534,
SLC2A8,
KIF25,
CCSER1,
MLLT4,
DKFZp686K1684,
MYO9A,
PCSK5,
WWOX,
PPL,
ANKS1B,
PTPRG,
RCN1,
ROBO2,
SRR,
PIEZO2,
TP53AIP1,
LOC654841,
SSTR1,
TPD52,
DIRC3,
CACNB2,
ULBP3,
ADAM12,
ID2B,
C4orf17,
GARNL3,
TCHP,
ANKRD13A,
CCND3,
EFCAB11,
DRC1,
NRXN1,
OTOF,
VGLL4,
SEC14L5,
ARHGAP32,
GIT2
|
| 22669977 |
Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness. J Biol Chem Magali M Le Goff , Matthew J Sutton , Mark Slevin , Ayse Latif , Martin J Humphries , Paul N Bishop |
2012-08-10 | - |
| 22534113 |
Cytokine Jin Ma , Tie Pei Zhu , Morten C Moe , Panpan Ye , Ke Yao |
2012-07-01 |
OPTC,
MMP2,
VEGFA
|
| 22082156 |
A whole genome screen for HIV restriction factors. Retrovirology Li Liu , Nidia M M Oliveira , Kelly M Cheney , Corinna Pade , Hanna Dreja , Ann-Marie H Bergin , Viola Borgdorff , David H Beach , Cleo L Bishop , Matthias T Dittmar , Aine McKnight |
2011-01-01 |
SLC35B1,
RAPGEF3,
CTSC,
MRPL54,
AP2M1,
TMEM266,
NR2C2AP,
SHE,
COL4A3,
R3HDML,
LELP1,
ALDH1L2,
DAG1,
DNM2,
DSP,
E2F1,
ELF3,
ESRRA,
EVI2B,
ALCAM,
MARCH8,
FAM83B,
EFR3A,
RTF1,
RPRD2,
FAM208A,
FUCA2,
FUT1,
ALX3,
RNF19A,
GANC,
GAP43,
ZNF658,
OPTC,
PELP1,
GNG3,
INO80E,
COX18,
GSTZ1,
RAB37,
ICAM4,
KLK3,
JUNB,
KCNG1,
KCNN1,
ZNF761,
FADS3,
PATE2,
MPI,
LRRC24,
NIT1,
OSM,
CCDC53,
COX16,
THEM6,
POP5,
CHMP5,
NCKIPSD,
POLB,
PAF1,
TXNL4B,
WSB2,
NDUFA12,
KLHL7,
PCDHB8,
IL36G,
INPP5E,
TRIM27,
HAPLN2,
SCD,
MRPL17,
ALDH8A1,
SEBOX,
PLA2G2F,
SLC26A10,
SYT4,
ACTC1,
UQCRH,
ZNF124,
MKRN3,
TRIM25,
LRRC2,
SPAG16,
NPEPL1,
RMI1,
ZNF556,
ZNF430,
ZNF93,
INO80B,
HIST1H2BC,
C18orf21,
NLRC5,
MEX3B,
HSDL2,
FKBP6,
TMEM209,
DGKD,
B4GALT3,
GCNT3
|
| 20201926 |
Human variation in alcohol response is influenced by variation in neuronal signaling genes. Alcohol. Clin. Exp. Res. Geoff Joslyn , Ajay Ravindranathan , Gerry Brush , Marc Schuckit , Raymond L White |
2010-05-01 |
CDH13,
LRPPRC,
CPQ,
FBLN5,
SORBS1,
PAICS,
RAD51AP1,
CPLX1,
PDE10A,
AKR1C4,
ADAMTS13,
ADAMTS8,
PTPRT,
POU6F2,
CHRM1,
CHRM2,
CHRNA1,
SYNPO,
CHRNA2,
CHRNA3,
CHRNA4,
CHRNA5,
CHRNB4,
EFHC1,
CHRND,
CNGB1,
COL4A2,
COL4A3,
VCAN,
CNTN4,
ADRB2,
AKR1C1,
DLG1,
DLG4,
DMP1,
DYNC1I1,
DOCK2,
DSPP,
EGF,
ERCC4,
EYA2,
FAH,
FBLN2,
FBN2,
FGF5,
NLGN1,
MYO16,
FOXC2,
ERC1,
FLT3,
KIF13B,
DICER1,
OR52A1,
PDSS1,
ABL1,
GAD1,
GAD2,
GALR1,
ERC2,
OPTC,
LHX6,
NUFIP1,
GHSR,
PDE7B,
ZNF638,
GLI2,
GLRB,
PCLO,
GLUD1,
GNAS,
GOT1,
GRK5,
GRIK1,
GRIK4,
GRIN2B,
GRM4,
GRM7,
GRM8,
GSTZ1,
GUCY2D,
HGD,
HLF,
HMGA1,
HNRNPA2B1,
IRF8,
IGF1R,
IMPG1,
IDO1,
ITGA2,
ITGB2,
KCNH1,
LAMB1,
ASIC2,
MAT1A,
MATN3,
ASPA,
MSH2,
ZFHX3,
MYL5
|
| 19536175 |
Eur J Hum Genet Georg B Ehret , Ashley A O'Connor , Alan Weder , Richard S Cooper , Aravinda Chakravarti |
2009-12-01 | - |
| 19844586 |
An evaluation of OPTC and EPYC as candidate genes for high myopia. Mol. Vis. Panfeng Wang , Shiqiang Li , Xueshan Xiao , Xiangming Guo , Qingjiong Zhang |
2009-01-01 |
EPYC,
OPTC
|
| 18164633 |
Osteoarthr. Cartil. J Monfort , G Tardif , P Roughley , P Reboul , C Boileau , P N Bishop , J-P Pelletier , J Martel-Pelletier |
2008-07-01 | - |
| 17474147 |
Proteomics Chenggang Wu , Mike Haiting Ma , Kevin R Brown , Matt Geisler , Lei Li , Eve Tzeng , Christina Y H Jia , Igor Jurisica , Shawn S-C Li |
2007-06-01 |
HDAC6,
HCN4,
CHAF1A,
CDH11,
PRG4,
HNRNPR,
SF3B4,
EFS,
TRAIP,
SEC24B,
RPP38,
CENPA,
TGOLN2,
CELF2,
PNMA2,
ZNF274,
EHMT2,
FASTK,
BAZ2A,
MAP4K5,
MAP4K1,
AKAP2,
NXPH3,
GPR45,
CSMD2,
OSBPL5,
CNTFR,
UHMK1,
DUSP15,
ALS2CR12,
CRK,
CRYBB3,
CSF2RA,
DAB2,
DAG1,
DARS,
GSX2,
ASXL1,
DLG4,
DLX4,
DNM1,
AGER,
DNASE1L2,
DNM2,
DOCK1,
DOCK3,
ABAT,
DTX1,
ECT2,
EFNA5,
CELSR3,
CELSR2,
AHSG,
ELK3,
EPS15,
EXTL1,
EXTL3,
F2RL2,
FANCA,
FCGR2B,
DLGAP4,
CD93,
SHANK2,
FOXF2,
TPX2,
RIMS1,
SPEN,
FOXJ1,
TNIK,
CUL9,
NFASC,
EPB41L3,
FLNA,
FLNB,
FLNC,
VPS13A,
SASH1,
AFF2,
ADNP,
BRD4,
TGDS,
CD2AP,
NR5A1,
ABL1,
FYB,
FYN,
GABBR1,
GABRA3,
GAD1,
NELFB,
MYRIP,
DNM3,
OPTC,
HIBCH,
GCDH,
GHR,
NBEA,
RPUSD2,
DKKL1
|
| 17359525 |
BMC Mol. Biol. Moulinath Acharya , Suddhasil Mookherjee , Ashima Bhattacharjee , Sanjay K D Thakur , Arun K Bandyopadhyay , Abhijit Sen , Subhabrata Chakrabarti , Kunal Ray |
2007-01-01 |
OPTC
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员