| Type | Description |
|---|---|
| Definition | F-box and leucine rich repeat protein 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 12:44:00 | This study has identified an iron-sulfur cluster within FBXL5, which promotes IRP2 polyubiquitination and degradation in response to both iron and oxygen concentrations. | 32126207 |
| 2020-05-09 13:04:00 | Dysregulation of FBXL5-mediated cellular iron homeostasis was found to be associated with poor prognosis in human hepatocellular carcinoma, suggesting that FBXL5 plays a key role in defense against hepatocarcinogenesis. | 30877170 |
| 2020-01-25 14:06:00 | We demonstrate that the CIA-targeting complex promotes the ability of FBXL5 to degrade iron regulatory proteins. In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation | 31229404 |
| 2019-06-01 11:34:00 | MiR-1306-3p directly targets FBXL5 and modulates FBXL5-meadiated snail protein stability in hepatocellular carcinoma. | 30219228 |
| 2019-01-05 10:46:00 | this study demonstrated that FBXL5 functioned as an oncogene in the progression of colon cancer through regulating PTEN/PI3K/AKT signaling | 30257389 |
| Type | IDs |
|---|---|
| Synonymous | FBL4, FBL5, FLR1 |
| Gene |
UniProtKB-ID:
FBXL5_HUMAN
UniprotKB:
Q9UKA1
UniParc:
UPI0000035C83,
UPI00001D6A20
EMBL:
AF142481,
BX537957,
AC116651,
BC030656,
AK295510,
CH471069,
AK000153,
AF174591,
AC114744,
AF157323,
AF176700,
AF199420
Ensembl:
ENSG00000118564
KO:
hsa:26234
|
| Nucleutide sequences |
EMBL-CDS:
BAA90978.1,
AAF66616.1,
CAD97924.1,
AAF04512.1,
BAG58427.1,
AAH30656.1,
AAY40929.1,
AAF67489.1,
AAF03700.1,
EAW92737.1,
AAF09249.1,
EAW92739.1
Ensembl_TRS:
ENST00000412094,
ENST00000341285
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000408679,
ENSP00000344866
RefSeq:
XP_011512135.1,
XP_016863508.1,
XP_006714022.1,
NP_001180463.1,
NP_001180464.1,
NP_036293.1,
XP_011512134.1,
XP_011512133.1
|
| Others |
UniRef100:
UniRef100_Q9UKA1
UniRef90:
UniRef90_Q9UKA1
UniRef50:
UniRef50_Q9UKA1
UniGene:
Hs.643433,
Hs.714386
CCDS:
CCDS54745.1,
CCDS3415.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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