| Type | Description |
|---|---|
| Definition | growth arrest specific 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:03:00 | Growth arrest-specific 2 protein family: Structure and function. | 33103301 |
| 2020-02-15 13:00:00 | GAS2 protein expression was lower in hepatocellular carcinoma (HCC) than in normal tissues. Overexpression of GAS2 inhibited the proliferation of HCC cells with wide type p53, while knockdown of GAS2 promoted the proliferation of hepatocytes. Results suggest that GAS2 plays a vital role in HCC cell proliferation and apoptosis, possibly by regulating the cell cycle and p53-dependent apoptosis pathway. | 31528096 |
| 2019-01-26 11:51:00 | This study found a highly significant correlation between colorectal cancers relapse and growth arrest-specific 2 (GAS2) gene expression. Based on cell models, the overexpressed GAS2 was associated with cellular growth rate, cell cycle regulation, and with chemotherapeutic sensitivity. | 27085973 |
| 2016-07-02 10:58:00 | Taken together, our results demonstrated the deregulation of GAS2 in both AML and ALL and the requirement of GAS2-Calpain2 axis for the growth of leukemic cells. | 26358320 |
| 2015-11-07 11:55:00 | Truncated HBx deregulates cell growth via direct silencing of GAS2 and thereby provides a survival advantage for pre-neoplastic hepatocytes to facilitate cancer development via TP53 signaling. | 25925944 |
| Type | IDs |
|---|---|
| Synonymous | GAS-2 |
| Gene |
UniProtKB-ID:
GAS2_HUMAN
UniprotKB:
O43903
UniParc:
UPI000000D98C,
UPI00001A3E68
EMBL:
BC040470,
AC006299,
AC103801,
CR450285,
U95032,
CH471064,
BC013326,
AK313734
Ensembl:
ENSG00000148935
KO:
hsa:2620
|
| Nucleutide sequences |
EMBL-CDS:
AAH13326.1,
AAH40470.1,
BAG36475.1,
EAW68317.1,
CAG29281.1,
EAW68318.1,
AAC52058.1
Ensembl_TRS:
ENST00000524701,
ENST00000454584,
ENST00000278187,
ENST00000630668
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000432026,
ENSP00000278187,
ENSP00000401145,
ENSP00000485708
RefSeq:
NP_808221.1,
NP_005247.1,
NP_001338153.1,
XP_011518273.1,
XP_016873021.1,
XP_011518274.1,
XP_011518277.1,
NP_001137302.1
|
| Others |
UniRef100:
UniRef100_O43903
UniRef90:
UniRef90_P11862
UniRef50:
UniRef50_P11862
UniGene:
Hs.711297
CCDS:
CCDS7858.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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