| Type | Description |
|---|---|
| Definition | HECT and RLD domain containing E3 ubiquitin protein ligase 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 11:19:00 | HERC4 is downregulated in NSCLC samples; HERC4 interacts with Smo reciprocally in NSCLC cells; knockdown of herc4 activates Hh pathway and promotes NSCLC cell proliferation. Taken together, our studies have demonstrated that HERC4 acts as a tumor suppressor via destabilizing the oncoprotein Smo | 31010679 |
| 2020-05-16 13:03:00 | The authors findings demonstrate that HERC4 is important for promoting tumorigenesis. | 30710319 |
| 2019-09-28 11:08:00 | the SIRT1/HERC4 locus on chromosome 10 was identified to be associated with intravenous (iv) bisphosphonates induced Osteonecrosis of the Jaw. | 28856724 |
| 2017-09-09 13:01:00 | HERC4 has an effect on the occurrence and development of hepatoma carcinoma | 28430527 |
| 2015-12-05 11:22:00 | High HERC4 expression is associated with lung cancer. | 25684480 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
HERC4_HUMAN,
A0A024QZN8_HUMAN
UniprotKB:
Q5GLZ8,
A0A024QZN8
UniParc:
UPI0000F0A542,
UPI0000048005,
UPI00001F8DA4,
UPI00004C6F56,
UPI00004C6F57,
UPI00001A75E7
EMBL:
AB046813,
AY650033,
AY650034,
AY221963,
AC024258,
BC039600,
AL133551,
AL356741,
CH471083,
AY650032
Ensembl:
ENSG00000148634
KO:
hsa:26091
|
| Nucleutide sequences |
EMBL-CDS:
BAB13419.1,
AAH39600.1,
AAV66579.1,
AAV66578.1,
AAO65480.1,
AAV66580.1,
EAW54261.1,
EAW54263.1
Gene_ORFName:
hCG_2024473
Ensembl_TRS:
ENST00000395198,
ENST00000473533,
ENST00000277817,
ENST00000373700,
ENST00000492996,
ENST00000412272
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000378624,
ENSP00000422383,
ENSP00000416504,
ENSP00000277817,
ENSP00000362804,
ENSP00000423671
RefSeq:
XP_011537897.1,
NP_056416.2,
XP_024303701.1,
XP_011537894.1,
NP_001265115.1,
XP_011537895.1,
XP_024303696.1,
XP_016871530.1,
NP_001265116.1,
XP_011537899.1,
XP_024303700.1,
NP_001265114.1,
XP_024303698.1,
XP_024303699.1,
XP_024303697.1,
NP_071362.1,
XP_011537898.1,
XP_011537896.1,
XP_024303695.1
|
| Others |
UniRef100:
UniRef100_A0A024QZN8,
UniRef100_Q5GLZ8
UniRef90:
UniRef90_Q6PAV2
UniRef50:
UniRef50_Q6PAV2
UniGene:
Hs.51891
CCDS:
CCDS60542.1,
CCDS41533.1,
CCDS7274.1,
CCDS60541.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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