| Type | Description |
|---|---|
| Definition | Rho guanine nucleotide exchange factor 26 |
| Date | Results | Publications |
|---|---|---|
| 2018-11-30 16:41:00 | SGEF plays a role in activating RhoG during invadopodia disassembly | 28202690 |
| 2018-09-01 11:09:00 | High SGEF expression is associated with lung adenocarcinoma. | 29454349 |
| 2017-10-28 11:42:00 | Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes. | 28714974 |
| 2017-07-22 12:47:00 | yrosine phosphorylation of SGEF suppresses its interaction with RhoG, the elevation of RhoG activity, and SGEF-mediated promotion of cell migration. We identified tyrosine 530 (Y530), which is located within the Dbl homology domain, as a major phosphorylation site of SGEF by Src, and Y530F mutation blocked the inhibitory effect of Src on SGEF | 27437949 |
| 2016-12-17 10:46:00 | Data support evidence for SGEF role in both the promotion of cell invasion and cell survival signaling within glioblastoma tumors and promoting chemotherapeutic resistance. | 26764186 |
| Type | IDs |
|---|---|
| Synonymous | CSGEF, HMFN1864, SGEF |
| Gene |
UniProtKB-ID:
ARHGQ_HUMAN,
A0A140VJU4_HUMAN,
B3KXG0_HUMAN
UniprotKB:
Q96DR7,
A0A140VJU4,
B3KXG0
UniParc:
UPI0001D3BD00,
UPI00004A2817,
UPI0001D3BCFF,
UPI00001410D0
EMBL:
AK022884,
BC078655,
AF415175,
FJ695204,
AY552599,
HM005484,
AF415176,
AL117429,
AK127282,
AC018452,
AK123040,
AB073386,
AK022655,
BC016628
Ensembl:
ENSG00000114790,
ENSG00000277101
KO:
hsa:26084
|
| Nucleutide sequences |
EMBL-CDS:
BAG53860.1,
BAB14159.1,
BAB14292.1,
AAH78655.1,
CAB55918.1,
AAL27001.1,
BAD38637.1,
AAS59842.1,
AAL27002.1,
AAH16628.1,
AEE61081.1,
BAG54472.1
Gene_ORFName:
HMFN1864
Ensembl_TRS:
ENST00000465817,
ENST00000356448,
ENST00000496710,
ENST00000614308,
ENST00000618535,
ENST00000630729,
ENST00000465093,
ENST00000629129
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000423295,
ENSP00000348828,
ENSP00000481927,
ENSP00000484367,
ENSP00000487265,
ENSP00000424446,
ENSP00000486665,
ENSP00000423418
RefSeq:
XP_016861649.1,
NP_001238892.1,
NP_001238891.1,
XP_011510974.1,
NP_056410.3
|
| Others |
UniRef100:
UniRef100_Q96DR7,
UniRef100_B3KXG0
UniRef90:
UniRef90_Q96DR7
UniRef50:
UniRef50_Q96DR7
UniGene:
Hs.240845
CCDS:
CCDS58858.1,
CCDS46938.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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