| Type | Description |
|---|---|
| Definition | DNA polymerase delta interacting protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 14:38:00 | Poldip2 deficiency in human aortic vascular smooth muscle in vitro induces the expression of the SRF , myocardin, and MRTFA and dramatically represses KLF4. Poldip2 deficiency upregulates the hexosamine biosynthetic pathway and OGT (O-linked N-acetylglucosamine transferase)-mediated protein O-GlcNAcylation. Poldip2 deficiency induces a highly differentiated phenotype in VSMCs by regulating metabolism and proteostasis. | 31656131 |
| 2020-07-25 11:28:00 | functional interaction of PolDIP2 with human DNA polymerases and the possible functions in DNA damage response | 32383114 |
| 2020-02-15 13:45:00 | Poldip2 and Ect2 are both essential for vascular smooth muscle cell cytokinesis and proliferation. | 30726115 |
| 2019-12-07 10:40:00 | The loss of PDIP38 consistently causes a shift in DNA damage tolerance (DDT) from error-prone translesion DNA synthesis (TLS) to error-free template switching (TS) without enhancing cellular sensitivity to DNA damage. We propose that PDIP38 controls the relative usage of TLS and TS increasing usage of TLS without changing the overall capability of DDT. | 30840704 |
| 2019-08-10 10:53:00 | Integrin engagement during cell attachment activates Poldip2/Nox4 to oxidize actin, which modulates filamentous actin assembly and its interaction with vinculin. | 30354218 |
| Type | IDs |
|---|---|
| Synonymous | PDIP38, POLD4, p38 |
| Gene |
UniProtKB-ID:
PDIP2_HUMAN,
B4DEM9_HUMAN
UniprotKB:
Q9Y2S7,
B4DEM9
UniParc:
UPI00017A6BD0,
UPI00000722ED
EMBL:
KF573649,
AF077203,
AC002094,
AK293707,
AF179891,
BC009265,
BC000655,
AK313232
Ensembl:
ENSG00000004142
KO:
hsa:26073
|
| Nucleutide sequences |
EMBL-CDS:
AAH00655.1,
AAH09265.1,
BAG36043.1,
AAK92018.1,
AAD26998.1,
BAG57140.1
Gene_ORFName:
HSPC017
Ensembl_TRS:
ENST00000540200,
ENST00000618887
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000475924,
ENSP00000477665
RefSeq:
NP_001277074.1,
NP_056399.1
|
| Others |
UniRef100:
UniRef100_Q9Y2S7,
UniRef100_B4DEM9
UniRef90:
UniRef90_Q9Y2S7,
UniRef90_U3KMR0
UniRef50:
UniRef50_Q91VA6,
UniRef50_Q9Y2S7
UniGene:
Hs.241543
CCDS:
CCDS74018.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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