| Type | Description |
|---|---|
| Definition | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:39:00 | APPL1 as an important regulator of insulin and adiponectin-signaling pathways in the PCOS: A narrative review. | 32339379 |
| 2019-09-14 10:29:00 | we demonstrate a novel role for the interaction between APPL1 and Rab5 in governing crosstalk between signaling and trafficking pathways on endosomes to affect cancer cell migration | 29361527 |
| 2018-05-19 10:12:00 | Present study demonstrated that expression of APPL1 protein and mRNA was upregulated in gastric carcinoma (GC) tissues and cell lines. The expression of APPL1 in GC was statistically associated with metastasis stage. Overexpression of APPL1 promotes invasion and metastasis of gastric cancer cells and the underlying molecular mechanism may facilitate EMT via Akt2 phosphorylation. | 28902365 |
| 2017-07-01 12:44:00 | APPL1 positively mediated leptin signaling. | 27820851 |
| 2017-04-29 10:38:00 | Decreased expression of APPL1 is associated with polycystic ovary syndrome. | 27075719 |
| Type | IDs |
|---|---|
| Synonymous | APPL, DIP13alpha, MODY14 |
| Gene |
UniProtKB-ID:
DP13A_HUMAN
UniprotKB:
Q9UKG1
UniParc:
UPI00000712DA
EMBL:
BC028599,
AF424738,
AF169797,
AB037849
Ensembl:
ENSG00000157500
KO:
hsa:26060
|
| Nucleutide sequences |
EMBL-CDS:
AAL17835.1,
BAA92666.2,
AAF04012.1,
AAH28599.1
Ensembl_TRS:
ENST00000650354,
ENST00000288266
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000288266,
ENSP00000498115
RefSeq:
XP_011531885.1,
NP_036228.1
|
| Others |
UniRef100:
UniRef100_Q9UKG1
UniRef90:
UniRef90_Q9UKG1
UniRef50:
UniRef50_Q9UKG1
UniGene:
Hs.476415
CCDS:
CCDS2882.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员