| Type | Description |
|---|---|
| Definition | glucuronic acid epimerase |
| Date | Results | Publications |
|---|---|---|
| 2020-03-07 11:52:00 | Results found the expression of GLCE is significantly decreased in the brains of frontotemporal lobar degeneration cases relative to normal controls, demonstrating the potential disease relevance of the candidate gene identified. Furthermore, knockdown of GLCE in cultured human cells protects against oxidative stress induced pTDP accumulation. | 31834878 |
| 2019-05-25 11:02:00 | Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase. | 30872481 |
| 2018-05-05 12:21:00 | Results show that overexpression of Hsepi alone resulted in an unexpected increase in heparan sulfate (HS) chain length. A Hsepi point-mutant (Y168A), devoid of catalytic activity, failed to affect chain length. Moreover, the effect of Hsepi overexpression on HS chain length was abolished by simultaneous overexpression of 2OST. | 27511124 |
| 2017-10-14 12:02:00 | The obtained data suggest an involvement of GLCE rs3865014 in breast cancer development. Heterozygous AG genotype might be a risk factor for breast cancer susceptibility in Siberian women and is associated with aggressive ER-negative and triple-negative cancer subtypes. | 28734894 |
| 2017-06-03 11:38:00 | The GLCE gene polymorphism rs3865014 appears to have biological relevance in human pathophysiology. | 27699767 |
| Type | IDs |
|---|---|
| Synonymous | HSEPI |
| Gene |
UniProtKB-ID:
GLCE_HUMAN
UniprotKB:
O94923
UniParc:
UPI00001D7785
EMBL:
AB020643,
AY635582,
AC026992
Ensembl:
ENSG00000138604
KO:
hsa:26035
|
| Nucleutide sequences |
EMBL-CDS:
AAT48654.1,
BAA74859.1
Ensembl_TRS:
ENST00000261858
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000261858
RefSeq:
XP_005254355.1,
NP_001311022.1,
NP_001311020.1,
NP_001311023.1,
NP_001311021.1,
XP_016877563.1,
NP_056369.1,
XP_016877562.1
|
| Others |
UniRef100:
UniRef100_O94923
UniRef90:
UniRef90_O94923
UniRef50:
UniRef50_O94923
UniGene:
Hs.183006
CCDS:
CCDS32277.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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