| Type | Description |
|---|---|
| Definition | inhibitor of Bruton tyrosine kinase |
| Date | Results | Publications |
|---|---|---|
| 2019-05-04 11:01:00 | RNA interference of Inhibitor of brutons tyrosine kinase-isoform alpha up regulated the expression of pro-apoptotic genes, including TNF, CRADD, CASP7, BNIP3 and BIRC3 and is a novel marker of CLL progression promoting cell growth and resistance to apoptosis. | 29317636 |
| 2017-09-16 11:59:00 | Data suggest that IBTKalpha is (a) localized in hepatocytes in endoplasmic reticulum (ER), (b) associates with specific proteins (LC3b, SEC16A, SEC31A), and (c) plays role in autophagy. Progression of nonalcoholic fatty liver disease is associated with changes in liver: (a) up-regulation of expression of IBTKalpha, (b) unfolded protein response, (c) ER stress, and (d) inhibition of autophagy. | 28710282 |
| 2017-04-08 10:06:00 | The results indicate that IBTKa differently modulates gene expression and RNA splicing in HeLa and K562 cells, demonstrating a novel biological role of this protein. | 27827994 |
| 2015-08-22 10:49:00 | CRL3(IBTK) is a novel ubiquitin ligase with regulatory roles in cellular pathways, such as the Pdcd4-dependent translation of mRNAs | 25882842 |
| 2015-01-17 12:24:00 | Depletion of IBTKalpha by short hairpin RNA reduced viability of cultured cells coincident with increased caspase 3/7 cleavage, suggesting that IBTKalpha is a key regulator in determining cell fate during the UPR. | 24648495 |
| Type | IDs |
|---|---|
| Synonymous | BTBD26, BTKI |
| Gene |
UniProtKB-ID:
IBTK_HUMAN,
B7ZLE0_HUMAN,
E7EPI0_HUMAN
UniprotKB:
Q9P2D0,
B7ZLE0,
E7EPI0
UniParc:
UPI000067CA93,
UPI000041929F,
UPI0001D3BBE0,
UPI000067CA94,
UPI000189A75E
EMBL:
AB037838,
BC042171,
BC143745,
DQ005633,
BC113696,
DQ005634,
BC113698,
AL050018,
BC038244,
DQ005635,
AF235049,
BC027490,
AL050333
Ensembl:
ENSG00000283068,
ENSG00000005700
KO:
hsa:25998
|
| Nucleutide sequences |
EMBL-CDS:
AAY55907.1,
AAI13697.1,
AAH27490.1,
AAY55906.1,
AAI13699.1,
AAY55908.1,
BAA92655.2,
AAH42171.2,
CAB43239.1,
AAH38244.2,
AAG27170.1,
AAI43746.1
Ensembl_TRS:
ENST00000306270,
ENST00000635454,
ENST00000635384,
ENST00000510291
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000489389,
ENSP00000305721,
ENSP00000426405,
ENSP00000489548
RefSeq:
NP_001287835.1,
XP_006715516.1,
XP_006715517.1,
NP_056340.2
|
| Others |
UniRef100:
UniRef100_Q9P2D0,
UniRef100_B7ZLE0,
UniRef100_E7EPI0
UniRef90:
UniRef90_E7EPI0,
UniRef90_Q9P2D0
UniRef50:
UniRef50_Q9P2D0
UniGene:
Hs.306425
CCDS:
CCDS34490.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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