| Type | Description |
|---|---|
| Definition | tsukushi, small leucine rich proteoglycan |
| Date | Results | Publications |
|---|---|---|
| 2020-09-05 13:53:00 | The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis. | 31391339 |
| 2020-02-29 10:36:00 | in lung cancer cells, TSK is expressed more highly than the other small leucine-rich repeat proteoglycan family members, and regulates the epithelial-mesenchymal transition and cell proliferation | 31027686 |
| 2019-05-18 11:45:00 | Among its predicted target genes down-regulated by miR-2110, knockdown of Tsukushi (TSKU) expression showed the most potent effect in inducing cell differentiation and reducing cell survival, suggesting that TSKU protein plays a key role in mediating the functions of miR-2110. Low tumor miR-2110 levels were significantly correlated with high tumor TSKU mRNA levels. | 30550571 |
| 2013-03-02 10:57:00 | TSK controls the hair cycle by regulating TGF-beta1 signaling. | 22995554 |
| 2013-01-12 10:19:00 | The spatio-temporal expression of Decorin, Semaphorin6D, Spry-1 and Tsukushi in developing prostate is described and observed similar mesenchymal expression patterns in rat and human. | 22880013 |
| Type | IDs |
|---|---|
| Synonymous | E2IG4, LRRC54, TSK |
| Gene |
UniProtKB-ID:
TSK_HUMAN,
A0A024R5J8_HUMAN,
B3KRF9_HUMAN
UniprotKB:
Q8WUA8,
A0A024R5J8,
B3KRF9
UniParc:
UPI00003E2893,
UPI000006E7B7
EMBL:
AL110276,
AK091475,
CH471076,
BC020975,
BT007440,
AY358317,
AF191019,
AK075476
Ensembl:
ENSG00000182704
KO:
hsa:25987
|
| Nucleutide sequences |
EMBL-CDS:
AAQ88683.1,
CAB53711.1,
AAF09483.1,
AAP36108.1,
AAH20975.1,
BAG52149.1,
EAW75005.1,
EAW75007.1,
EAW75006.1,
BAG52371.1
Gene_ORFName:
UNQ850/PRO1788,
hCG_41868
Ensembl_TRS:
ENST00000333090,
ENST00000612930,
ENST00000527881
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000482145,
ENSP00000332668,
ENSP00000434847
RefSeq:
NP_001305406.1,
NP_056331.2,
NP_001305407.1,
NP_001245139.1,
NP_001305408.1
|
| Others |
UniRef100:
UniRef100_B3KRF9,
UniRef100_Q8WUA8
UniRef90:
UniRef90_A0A0D9S949,
UniRef90_Q8WUA8
UniRef50:
UniRef50_Q8CBR6,
UniRef50_Q5M7S9
UniGene:
Hs.8361
CCDS:
CCDS8246.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31391339 |
The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis. JCI Insight Mathilde Mouchiroud , Ãtienne Camiré , Manal Aldow , Alexandre Caron , Ãric Jubinville , Laurie Turcotte , Inès Kaci , Marie-Josée Beaulieu , Christian Roy , Sébastien M Labbé , Thibault V Varin , Yves Gélinas , Jennifer Lamothe , Jocelyn Trottier , Patricia L Mitchell , Frédéric Guénard , William T Festuccia , Philippe Joubert , Christopher F Rose , Constantine J Karvellas , Olivier Barbier , Mathieu C Morissette , André Marette , Mathieu Laplante |
2019-08-08 | - |
| 31027686 |
Significance of Tsukushi in lung cancer. Lung Cancer Tatsuya Yamada , Kunimasa Ohta , Yamato Motooka , Kosuke Fujino , Shinji Kudoh , Yuki Tenjin , Younosuke Sato , Akira Matsuo , Koei Ikeda , Makoto Suzuki , Takaaki Ito |
2019-05-01 | - |
| 30550571 |
microRNA-2110 functions as an onco-suppressor in neuroblastoma by directly targeting Tsukushi. PLoS One Zhenze Zhao , Veronica Partridge , Michaela Sousares , Spencer D Shelton , Cory L Holland , Alexander Pertsemlidis , Liqin Du |
2018-01-01 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 22995554 |
Tsukushi controls the hair cycle by regulating TGF-β1 signaling. Dev Biol Daisuke Niimori , Rie Kawano , Athary Felemban , Kanako Niimori-Kita , Hideaki Tanaka , Hironobu Ihn , Kunimasa Ohta |
2012-12-01 | - |
| 22880013 |
PLoS ONE Alexander Henke , O Cathal Grace , George R Ashley , Grant D Stewart , Antony C P Riddick , Henry Yeun , Marie O'Donnell , Richard A Anderson , Axel A Thomson |
2012-01-01 | - |
| 19710929 |
PLoS One Maryam Rakhshandehroo , Guido Hooiveld , Michael Müller , Sander Kersten |
2009-08-27 | - |
| 16344560 |
Genome Res. Kouichi Kimura , Ai Wakamatsu , Yutaka Suzuki , Toshio Ota , Tetsuo Nishikawa , Riu Yamashita , Jun-ichi Yamamoto , Mitsuo Sekine , Katsuki Tsuritani , Hiroyuki Wakaguri , Shizuko Ishii , Tomoyasu Sugiyama , Kaoru Saito , Yuko Isono , Ryotaro Irie , Norihiro Kushida , Takahiro Yoneyama , Rie Otsuka , Katsuhiro Kanda , Takahide Yokoi , Hiroshi Kondo , Masako Wagatsuma , Katsuji Murakawa , Shinichi Ishida , Tadashi Ishibashi , Asako Takahashi-Fujii , Tomoo Tanase , Keiichi Nagai , Hisashi Kikuchi , Kenta Nakai , Takao Isogai , Sumio Sugano |
2006-01-01 |
Nefm,
MED6,
CDH2,
PDZK1P1,
DDTL,
ABI1,
GNPDA1,
GTF2IP4,
ZSCAN30,
SRA1,
TMEM170B,
HOTAIR,
FAM86JP,
LOC100126784,
C8orf88,
LOC100128006,
RAB28P5,
MYHAS,
CDC42P3,
LOC100128979,
LOC100128993,
KTN1-AS1,
LOC100129083,
LOC100129204,
TOPORS-AS1,
LINC00484,
ZNF37BP,
FAM47E,
MRVI1-AS1,
ZNF737,
LOC100130075,
MAPT-IT1,
MIR124-2HG,
LINC00861,
LOC100130238,
LOC100130357,
PARD6G-AS1,
LOC100130547,
NFYC-AS1,
EFCAB10,
LOC100130798,
SBK3,
LOC100130849,
LOC100130872,
LOC100130880,
LOC100130987,
LOC100131047,
LINC01135,
CKMT2-AS1,
ZBTB20-AS1,
WDR86-AS1,
CCDC183-AS1,
SNAP25-AS1,
NEMP2,
ZNF503-AS2,
MIR181A1HG,
DBIL5P,
HDAC6,
MZF1-AS1,
ARMCX4,
LINC00271,
ZNF717,
LOC100132057,
LOC100132111,
CALML3-AS1,
NDUFA6-AS1,
FRG1HP,
FCGR1CP,
GXYLT1P3,
GOLGA8F,
DCAF13P3,
IPO5P1,
MSC-AS1,
SMIM9,
FAM66A,
CD24,
UXT-AS1,
JHDM1D-AS1,
UBE2Q2P2,
TEN1,
JMJD7,
PLA2G4B,
LINC00930,
PDCD6IP,
HECTD2-AS1,
ZFHX4-AS1,
FAR2P2,
LOC100233156,
PCED1B-AS1,
PIGK,
LOC100270746,
LOC100270804,
LINC00940,
ERVV-2,
MEF2B,
ZNRF2P2,
NFE2L3P2,
LINC00894,
BCDIN3D-AS1
|
| 16303743 |
DNA Res. Tetsuji Otsuki , Toshio Ota , Tetsuo Nishikawa , Koji Hayashi , Yutaka Suzuki , Jun-ichi Yamamoto , Ai Wakamatsu , Kouichi Kimura , Katsuhiko Sakamoto , Naoto Hatano , Yuri Kawai , Shizuko Ishii , Kaoru Saito , Shin-ichi Kojima , Tomoyasu Sugiyama , Tetsuyoshi Ono , Kazunori Okano , Yoko Yoshikawa , Satoshi Aotsuka , Naokazu Sasaki , Atsushi Hattori , Koji Okumura , Keiichi Nagai , Sumio Sugano , Takao Isogai |
2005-01-01 |
NAALAD2,
LOC100132356,
TMED7-TICAM2,
TSPAN3,
ATP6AP2,
CHST4,
CNIH1,
LOC101928215,
PSME3,
ZMPSTE24,
RTN3,
LAMC3,
B3GNT3,
TUBB4A,
CPQ,
SPON2,
SPON1,
SEMA4F,
FBLN5,
ATG7,
ARL6IP5,
SLC34A2,
POMT1,
PDPN,
DLL3,
LOC107133515,
PLAC1,
GJB6,
HPSE,
RUVBL2,
LYVE1,
BLCAP,
ADCY3,
B4GAT1,
SPACA9,
CACFD1,
PRSS23,
EMILIN1,
SLC2A6,
GALNT6,
SEC63,
PRRT2,
MAN1B1,
NRM,
RDH13,
GLMP,
CHRM3,
SCAMP4,
CHST14,
VSIG4,
SLC52A3,
FKBP9,
TEX261,
SMIM12,
PIK3IP1,
C1QTNF1,
C1QTNF3,
TMEM123,
LRRC42,
FAM210B,
LYPD1,
MRGPRF,
UBE2J2,
CLPTM1,
CANT1,
SLC43A2,
GGT6,
PUSL1,
DRAM2,
PIGU,
MBOAT2,
TMEM178A,
TRAM1L1,
TMEM139,
HGSNAT,
CRH,
CS,
FGFBP3,
LDLRAD3,
TMEM86A,
ISM2,
C16orf89,
SLC25A10,
LRRC37BP1,
C19orf25,
CTSB,
CTSL,
XXYLT1,
GLIPR2,
SLC38A9,
RNF145,
ATP6V0E2,
SLC16A11,
DEDD2,
APCDD1L,
UGT3A2,
DLX3,
DNASE2,
TOR1A
|
| 15489334 |
Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team |
2004-10-01 |
Ldlrap1,
Dnajc3,
Rnaset2a,
Btnl1,
Isg15,
Cyp3a41b,
Ly6c2,
Ccl21b,
Eif3j2,
Mup18,
Lrrc19,
Rcc1,
1700047I17Rik2,
Pcsk9,
Adat3,
Tdrd7,
Sco2,
Gpr153,
Pafah2,
Gm44504,
H6pd,
Adprhl2,
Gpn2,
Rusc2,
Stx12,
Ppp1r8,
Smpdl3b,
Fam46b,
Bsdc1,
Slc44a1,
Zfand2a,
Rubcn,
Kifc1,
Pifo,
C030017K20Rik,
Cbarp,
Rpl5,
Micalcl,
Atg14,
Lrrc8c,
Noc4l,
Nsun5,
Psph,
Trrap,
Mapre3,
Ube3c,
Tbc1d14,
Hscb,
Tyw1,
Emilin1,
Rab28,
Pot1a,
Parp11,
Tada3,
Tra2a,
Brk1,
Fbxl14,
Phrf1,
Plekha1,
Gm21975,
Ric8a,
Mob2,
Prkd2,
Ccp110,
Vrk3,
Grwd1,
Nlrp6,
Trim68,
Psip1,
Spred3,
Faap24,
Ints4,
Rrp8,
Unc45a,
Igflr1,
Sf3b3,
D8Ertd738e,
Usb1,
Champ1,
Smim19,
Exoc8,
Gadd45gip1,
Phkb,
Dohh,
Fam192a,
Enkd1,
Taf5l,
Zdhhc7,
Snapc2,
Ak6,
Gpat4,
Dcun1d2,
Ankrd10,
Cog4,
Hinfp,
Lars2,
Xylb,
Imp3,
Cmtm7
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员