| Type | Description |
|---|---|
| Definition | SH2B adaptor protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:38:00 | Association of the SH2B1 rs7359397 Gene Polymorphism with Steatosis Severity in Subjects with Obesity and Non-Alcoholic Fatty Liver Disease. | 32365683 |
| 2020-07-25 13:01:00 | Mice with LepR neuron-specific or adult-onset, hypothalamus-specific ablation of Sh2b1 develop obesity, insulin resistance, and liver steatosis. Hypothalamic overexpression of human SH2B1 protects against high fat diet-induced obesity and metabolic syndromes. Results unravel an unrecognized LepR neuron Sh2b1/ sympathetic nervous system/brown adipose tissue /thermogenesis axis that combats obesity and metabolic disease. | 32251290 |
| 2020-06-06 13:16:00 | provide a mini overview of the roles of SH2B1 in cancer. | 31739166 |
| 2020-04-04 12:36:00 | Hsa_circ_0136666 promotes the proliferation and invasion of colorectal cancer through miR-136/SH2B1 axis. | 30370521 |
| 2020-03-21 11:38:00 | These studies demonstrate that the PH domain plays a crucial role in how SH2B1 controls energy balance and glucose homeostasis. | 31439647 |
| Type | IDs |
|---|---|
| Synonymous | PSM, SH2B |
| Gene |
UniProtKB-ID:
SH2B1_HUMAN,
B4DLN5_HUMAN,
B3KNV5_HUMAN,
A0A024QZC2_HUMAN,
A0A024QZ92_HUMAN,
A0A024QZD2_HUMAN
UniprotKB:
Q9NRF2,
B4DLN5,
B3KNV5,
A0A024QZC2,
A0A024QZ92,
A0A024QZD2
UniParc:
UPI0000E028F5,
UPI0000246E38,
UPI0000D466A5,
UPI00004894E6,
UPI00001AF36C
EMBL:
AK027488,
AF227969,
BC010704,
AL049924,
AK290332,
AK297080,
AF227968,
AF227967,
AK055104,
AB037720,
AL713760,
CH471267,
AC133550
Ensembl:
ENSG00000178188
KO:
hsa:25970
|
| Nucleutide sequences |
EMBL-CDS:
BAB55148.1,
AAF73914.1,
BAA92537.1,
AAH10704.1,
AAF73912.1,
CAB43208.1,
BAF83021.1,
AAF73913.1,
CAD28530.1,
BAG59597.1,
BAG51467.1,
EAW52004.1,
EAW52000.1,
EAW52003.1,
EAW51999.1,
EAW52001.1,
EAW52005.1
Gene_ORFName:
hCG_18639,
hCG_18639,
hCG_18639
Ensembl_TRS:
ENST00000618521,
ENST00000322610,
ENST00000395532,
ENST00000337120,
ENST00000359285,
ENST00000538342
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000337163,
ENSP00000352232,
ENSP00000378903,
ENSP00000321221,
ENSP00000481709,
ENSP00000438784
RefSeq:
NP_001139267.1,
NP_001295223.1,
NP_001139284.1,
NP_056318.2,
NP_001139268.1,
NP_001139269.1,
NP_001374333.1,
NP_001295222.1,
NP_001374359.1
|
| Others |
UniRef100:
UniRef100_Q9NRF2,
UniRef100_A0A024QZ92,
UniRef100_B3KNV5,
UniRef100_A0A024QZC2
UniRef90:
UniRef90_Q9NRF2,
UniRef90_A0A0D9R1X1,
UniRef90_H0XH91
UniRef50:
UniRef50_Q9NRF2,
UniRef50_A0A0D9R1X1
UniGene:
Hs.15744
CCDS:
CCDS53997.1,
CCDS53996.1,
CCDS32424.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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