| Type | Description |
|---|---|
| Definition | CREB-regulated transcription coactivator 1 homolog |
| Date | Results | Publications |
|---|---|---|
| 2020-02-08 11:25:00 | Here, the authors show that neuronal AMPK is essential for lifespan extension from TORC1 inhibition, and that TORC1 suppression increases lifespan cell non autonomously via distinct mechanisms from global AMPK activation. | 31411562 |
| 2015-05-02 11:43:00 | Study shows that CRTC-1 specifically uncouples AMPK/calcineurin-mediated effects on lifespan from pleiotropic side effects by reprogramming mitochondrial and metabolic function. This pro-longevity metabolic state is regulated cell nonautonomously by CRTC-1 in the nervous system. | 25723162 |
| 2014-11-10 01:06:00 | Downregulation of crtc-1 increases lifespan in a crh-1-dependent manner and directly reducing crh-1 expression increases longevity, substantiating a role for CRTCs and CREB in ageing | 21331044 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
CRTC1_CAEEL
UniprotKB:
Q95XA8
UniParc:
UPI0002530C3D
EMBL:
FO081781
EnsemblGenome:
WBGene00021237
KO:
cel:CELE_Y20F4.2
|
| Nucleutide sequences |
EMBL-CDS:
CCD73417.2
Gene_ORFName:
Y20F4.2
EnsemblGenome_TRS:
Y20F4.2.1,
Y20F4.2.2
|
| Protein sequencees |
EnsemblGenome_PRO:
Y20F4.2.1,
Y20F4.2.2
RefSeq:
NP_490917.4
|
| Others |
UniRef100:
UniRef100_Q95XA8
UniRef90:
UniRef90_Q95XA8
UniRef50:
UniRef50_Q95XA8
UniGene:
Cel.20318
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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