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259307 IL4I1

259307

IL4I1

interleukin 4 induced 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition interleukin 4 induced 1

研究结论

Date Results Publications
2020-10-03 12:53:00 Lnc-C/EBPbeta Modulates Differentiation of MDSCs Through Downregulating IL4i1 With C/EBPbeta LIP and WDR5. 31379854
2019-09-14 11:45:00 these data show that IL4I1+ cells shape the T-cell compartment and are associated with a higher risk of poor outcome in melanoma, supporting a key role for IL4I1 in immune evasion. 30048651
2018-11-10 11:54:00 the presence of IL4I1 during T-cell activation decreases early signaling events downstream of t-cell receptor stimulation, resulting in global T-cell inhibition which is more pronounced when there is CD28 costimulation. 28891065
2018-07-21 12:11:00 Data showed proteome changes in alveolar epithelial cells type II exposed to an infection with A. fumigatus with IL4I1 showing the most prominent increase in abundance both, in terms of relative abundance as well as activity. Also, in the infected lungs, there was levels of IL4I1 metabolic products. 28951444
2017-01-28 11:15:00 reviewed SNPs of the IL4I1 isoform 1, which is expressed in lymphoid tissue; the N92D SNP leads to a hyperactive enzyme, while the R102G mutation is hypomorphic; show that IL4I1 activity is not only directed against phenylalanine, as initially described, but also at a lower level against arginine 26673964

名称对应

Type IDs
Synonymous FIG1, LAAO, LAO
Gene
UniProtKB-ID: OXLA_HUMAN
UniprotKB: Q96RQ9
UniParc: UPI00000359F4, UPI00001678CE
EMBL: DQ079589, AJ880386, AF293462, DQ079587, AJ880388, AY358933, AF293463, BC090852, CH471177, BC064378, DQ079588, AJ880387, AK074097
Ensembl: ENSG00000104951
KO: hsa:259307
Nucleutide sequences
EMBL-CDS: EAW52575.1, AAQ89292.1, BAB84923.1, CAI54292.1, AAZ32712.1, AAZ32711.1, AAH90852.2, AAK73363.1, AAK73362.1, CAI54293.1, AAH64378.2, CAI54291.1, AAZ32713.1
Gene_ORFName: UNQ636/PRO1265
Ensembl_TRS: ENST00000595948, ENST00000341114, ENST00000391826
Protein sequencees
Ensembl_PRO: ENSP00000472474, ENSP00000342557, ENSP00000375702
RefSeq: NP_001372568.1, NP_001244946.1, NP_001244947.1, NP_690863.1, NP_758962.1
Others
UniRef100: UniRef100_Q96RQ9
UniRef90: UniRef90_Q96RQ9
UniRef50: UniRef50_Q96RQ9
UniGene: Hs.574492, Hs.741750
CCDS: CCDS12786.1, CCDS12787.1

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