| Type | Description |
|---|---|
| Definition | EH-domain containing 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-14 12:22:00 | EHD2-controlled caveolar dynamics orchestrates the activity and regulation of eNOS/nitric oxide and Ca2+ channel localization at the plasma membrane. | 31600286 |
| 2018-11-10 12:22:00 | EHD2 may be cardioprotective as a dominant-negative EHD2 mutant sensitized cardiomyocytes to ischemic damage. Our findings highlight EHD2 as a potential pharmacologic target in the treatment of diseases with KATP channel trafficking defects | 29133341 |
| 2018-08-04 10:08:00 | EHD1, EHD2, and EHD4 are recruited to caveolae. Recruitment of the other EHDs increases markedly when EHD2, which has been previously detected at caveolae, is absent. Construction of knockout cell lines lacking EHDs 1, 2, and 4 confirms this apparent functional redundancy. | 28943089 |
| 2018-05-12 11:31:00 | The regulatory N-terminal residues and the EH domain keep the EHD2 dimer in an autoinhibited conformation in solution. By significantly advancing the use of infrared reflection-absorption spectroscopy, we demonstrate that EHD2 adopts an open conformation by tilting the helical domains upon membrane binding. | 28223496 |
| 2015-05-30 13:02:00 | The helical domain of EHD2 is inserted into the membrane.The N terminus domain regulates caveolar targeting of EHD2. | 24508342 |
| Type | IDs |
|---|---|
| Synonymous | BC027084, C130052H20Rik |
| Gene |
UniProtKB-ID:
EHD2_MOUSE
UniprotKB:
Q8BH64
UniParc:
UPI00000EB96C
EMBL:
AY531389,
BC113161,
AK050243,
AK084455,
AK031203,
AK085016,
AK046566,
AK048356
Ensembl:
ENSMUSG00000074364
KO:
mmu:259300
|
| Nucleutide sequences |
EMBL-CDS:
BAC39188.1,
BAC33310.1,
BAC39339.1,
AAS48536.1,
BAC27298.1,
BAC32789.1,
BAC34142.1,
AAI13162.1
Ensembl_TRS:
ENSMUST00000098799
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000096397
RefSeq:
XP_011248884.1,
NP_694708.2
|
| Others |
UniRef100:
UniRef100_Q8BH64
UniRef90:
UniRef90_Q8BH64
UniRef50:
UniRef50_Q8BH64
UniGene:
Mm.138215,
Mm.438817
CCDS:
CCDS20842.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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