| Type | Description |
|---|---|
| Definition | atlastin GTPase 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 12:45:00 | ATL3 functions as a receptor for endoplasmic reticulum (ER)-phagy, promoting tubular ER degradation upon starvation. ATL3 specifically binds to GABARAP, but not LC3, subfamily proteins via 2 GABARAP interaction motifs (GIMs). ATL3-GABARAP interaction is essential for ATL3 to function in ER-phagy. | 30773365 |
| 2019-12-07 11:40:00 | the effects of ATL3 mutations on endoplasmic reticulum network organization go beyond a loss of fusion and shed light on neuropathies caused by atlastin defects. | 29768202 |
| 2019-06-22 10:04:00 | the mitochondria in these cells display lowered motility, and the number of axonal mitochondria in neurons expressing disease-causing mutations in ATL3 is strongly decreased. These results underscore the functional interdependence of subcellular organelles in health and disease and show that disorders caused by ER-shaping defects are more complex than previously assumed. | 30339187 |
| 2019-03-30 11:52:00 | ATL3 Y192C delays endoplasmic reticulum-export by reducing the number of endoplasmic reticulum exit sites, reduces autophagy, fragments the Golgi and causes malformation of the nucleus. In cultured primary neurons, ATL3 Y192C does not localize to the growing axon, resulting in axon growth deficits. | 30666337 |
| 2018-06-02 10:36:00 | study reports that Sey1/Atl3 and Rtn4 localize to early Legionella-containing vacuoles (LCV) and are critical for pathogen vacuole formation; Sey1/Atl3-dependent ER remodeling contributes to LCV maturation and intracellular replication of L. pneumophila | 28835546 |
| Type | IDs |
|---|---|
| Synonymous | HSN1F |
| Gene |
UniProtKB-ID:
ATLA3_HUMAN,
B4DXC4_HUMAN,
F5H6I7_HUMAN
UniprotKB:
Q6DD88,
B4DXC4,
F5H6I7
UniParc:
UPI0000405967,
UPI00017A809B,
UPI0000071A21
EMBL:
AK023383,
BC077727,
AP000753,
AL117600,
AK097588,
KF455400,
AK301910
Ensembl:
ENSG00000184743
KO:
hsa:25923
|
| Nucleutide sequences |
EMBL-CDS:
BAB14552.1,
CAB56010.2,
AAH77727.1,
BAC05111.1,
BAG63336.1
Ensembl_TRS:
ENST00000398868,
ENST00000538786
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000381844,
ENSP00000437593
RefSeq:
NP_001276977.1,
XP_006718556.1,
NP_056274.3,
XP_024304196.1
|
| Others |
UniRef100:
UniRef100_B4DXC4,
UniRef100_Q6DD88,
UniRef100_F5H6I7
UniRef90:
UniRef90_Q91YH5,
UniRef90_Q91YH5-2,
UniRef90_Q6DD88
UniRef50:
UniRef50_Q91YH5,
UniRef50_Q6DD88
UniGene:
Hs.356719
CCDS:
CCDS41663.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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