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25902 MTHFD1L

25902

MTHFD1L

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like

protein-coding

Homo sapiens

基因描述

Type Description
Definition methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like

研究结论

Date Results Publications
2020-05-02 10:07:00 Results together with the limitations of the original studies indicate that the reported associations between the MTHFD1L and FOPNL loci and MM survival are false positives due to a winner's curse effect. 31363079
2018-11-10 10:04:00 MTHFD1L protein and RNA expression levels were significantly upregulated in esophageal squamous cell carcinoma tissue as compared with normal tissue. High expression of MTHFD1 was also detected in two esophageal cancer cell lines (TE-1 and EC109). 29171320
2017-09-16 11:57:00 study identifies MTHFD1L in the folate cycle as an important metabolic pathway in cancer cells with the potential for therapeutic targeting 28394261
2016-10-22 11:31:00 Studies reported that the A allele of a polymorphism in a gene involved in folate metabolism, MTHFD1L, showed a genome-wide significant association with late-onset Alzheimer's Disease. 26926881
2016-05-28 12:25:00 rs6922269 variant at MTHFD1L gene could be an important prognostic factor for cardiovascular mortality in patients after ACS. 25809277

名称对应

Type IDs
Synonymous FTHFSDC1, MTC1THFS, dJ292B18.2
Gene
UniProtKB-ID: C1TM_HUMAN, A0A087WVM4_HUMAN, B7ZM99_HUMAN, B2RD24_HUMAN
UniprotKB: Q6UB35, A0A087WVM4, B7ZM99, B2RD24
UniParc: UPI000166C73D, UPI00001CE514, UPI0002141D17, UPI000006FFF8, UPI00001CE513
EMBL: AY374131, BC008629, BC136685, BC110319, KF458323, AL049694, CH471051, AK315378, AY374130, AL117452, BC144368, AK024798, BC017477, AB127387, AL133260, AL035086
Ensembl: ENSG00000120254
KO: hsa:25902
Nucleutide sequences
EMBL-CDS: AAQ82697.1, AAH17477.2, BAB15009.1, AAI10320.1, BAD93193.1, AAQ82696.1, EAW47762.1, AAH08629.1, CAB55934.1, AAI36686.1, AAI44369.1, BAG37771.1
Ensembl_TRS: ENST00000367307, ENST00000367321, ENST00000618312, ENST00000611279
Protein sequencees
Ensembl_PRO: ENSP00000356276, ENSP00000356290, ENSP00000479539, ENSP00000478253
RefSeq: XP_011534036.1, XP_016866191.1, NP_001337415.1, XP_005266964.1, NP_001337422.1, NP_001229698.1, XP_016866194.1, NP_001337416.1, NP_001229697.1, NP_001229696.1, XP_016866192.1, NP_001337419.1, XP_024302164.1, XP_011534032.1, NP_001337421.1, XP_011534035.1, XP_011534039.1, XP_011534034.1, XP_005266968.1, NP_056255.2, XP_011534040.1, NP_001337417.1, XP_011534033.1, NP_001337418.1, NP_001337420.1, XP_011534031.1, XP_024302163.1
Others
UniRef100: UniRef100_A0A087WVM4, UniRef100_Q6UB35, UniRef100_B7ZM99
UniRef90: UniRef90_G3QM61, UniRef90_Q6UB35
UniRef50: UniRef50_Q6UB35
UniGene: Hs.591343
CCDS: CCDS5228.1, CCDS56457.1

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